NCT07484191

Brief Summary

The purpose of this study is to test new versions of Clareon Vivity Pro intraocular lenses (IOLs) by comparing them to currently marketed IOLs.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
231

participants targeted

Target at P75+ for not_applicable

Timeline
6mo left

Started Apr 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

7 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress34%
Apr 2026Feb 2027

First Submitted

Initial submission to the registry

March 16, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 20, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

April 28, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

July 10, 2026

Status Verified

July 1, 2026

Enrollment Period

5 months

First QC Date

March 16, 2026

Last Update Submit

July 9, 2026

Conditions

Keywords

CataractEye SurgeryIntermediate Vision

Outcome Measures

Primary Outcomes (1)

  • Mean monocular photopic distance-corrected intermediate visual acuity (DCIVA)

    Visual acuity (VA) will be assessed for each eye individually (monocular) with distance correction in place (plus or minus power) under photopic (well-lit) conditions at a distance of 66 centimeters (cm) from the spectacle plane using a visual acuity chart. VA will be measured in logarithm minimum angle of resolution (logMAR). A logMAR value of 0 equates to 20/20 Snellen visual acuity, with a lower logMAR value indicating better visual acuity.

    Month 1 postoperative

Study Arms (2)

Clareon Vivity Pro IOL / Clareon Vivity IOL (Sub-Study B)

OTHER

Clareon Vivity Pro IOL implanted in one eye, with Clareon Vivity IOL in the fellow eye, as randomized

Device: Clareon Vivity Pro IOLDevice: Clareon Vivity IOLProcedure: Cataract Surgery

Clareon Vivity Pro IOL / TECNIS PureSee IOL (Sub-Study C)

OTHER

Clareon Vivity Pro IOL implanted in one eye, with TECNIS PureSee IOL in the fellow eye, as randomized

Device: Clareon Vivity Pro IOLDevice: TECNIS PureSee IOLProcedure: Cataract Surgery

Interventions

Investigational UV-absorbing, blue-light filtering (BLF), foldable IOL that provides an extended range of vision from distance to near without increasing the incidence of visual disturbances. IOLs are implantable medical devices and are intended for long term use over the lifetime of the pseudophakic subject.

Clareon Vivity Pro IOL / Clareon Vivity IOL (Sub-Study B)Clareon Vivity Pro IOL / TECNIS PureSee IOL (Sub-Study C)

Currently marketed UV-absorbing, BLF, foldable IOL that provides an extended range of vision from distance to functional near without increasing the incidence of visual disturbances. IOLs are implantable medical devices and are intended for long term use over the lifetime of the pseudophakic subject.

Clareon Vivity Pro IOL / Clareon Vivity IOL (Sub-Study B)

Currently marketed UV absorbing, violet-light filtering IOL for primary implantation for the visual correction of aphakia in adult patients with and without presbyopia. IOLs are implantable medical devices and are intended for long term use over the lifetime of the pseudophakic subject.

Clareon Vivity Pro IOL / TECNIS PureSee IOL (Sub-Study C)

Removal of the cloudy lens, followed by implantation of the IOL

Clareon Vivity Pro IOL / Clareon Vivity IOL (Sub-Study B)Clareon Vivity Pro IOL / TECNIS PureSee IOL (Sub-Study C)

Eligibility Criteria

Age22 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Cataracts in both eyes.
  • Preoperative corneal astigmatism of less than 1.00 diopter (D) in each eye.
  • Potential postoperative best corrected visual acuity (BCDVA) of 0.2 logMAR or better in each eye in the expert medical opinion of the investigator.

You may not qualify if:

  • Desires monovision correction.
  • Predicted post-operative residual astigmatism of more than 1D in either eye.
  • Any ocular or systemic co-morbidity that, in the investigator's medical opinion, may confound the results of this study, prohibit the completion of the study assessments, or increase the risk for the subject.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (7)

iVision Clinic

Campsie, New South Wales, 2194, Australia

RECRUITING

Vision Eye Institute - Chatswood

Sydney, New South Wales, 2067, Australia

RECRUITING

Personaleyes Parramatta

Sydney, New South Wales, 2150, Australia

RECRUITING

Wollongong Eye Specialists

Wollongong, New South Wales, 2500, Australia

RECRUITING

Focus Vision

Woolloongabba, Queensland, 4102, Australia

RECRUITING

Eye Surgery Associates - East Melbourne

East Melbourne, Victoria, 3002, Australia

RECRUITING

Peninsula Eye Center

Mornington, Victoria, 3931, Australia

RECRUITING

Related Links

MeSH Terms

Conditions

AphakiaPresbyopiaCataract

Interventions

Cataract Extraction

Condition Hierarchy (Ancestors)

Lens DiseasesEye DiseasesRefractive Errors

Intervention Hierarchy (Ancestors)

Refractive Surgical ProceduresOphthalmologic Surgical ProceduresSurgical Procedures, Operative

Study Officials

  • Clinical Trial Lead, Surgical

    Alcon Research, LLC

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: In this contralateral study, subjects will receive Clareon Vivity Pro IOL in one eye and either Clareon Vivity IOL or TECNIS PureSee IOL in the other eye.
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 16, 2026

First Posted

March 20, 2026

Study Start

April 28, 2026

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

February 1, 2027

Last Updated

July 10, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations