NCT07481227|Completed
FS-LASIK Versus TransPRK for Mixed Astigmatism
Comparative Study of Femtosecond Laser-assisted LASIK and Single-step Transepithelial Photorefractive Keratectomy for Correction of Mixed Astigmatism
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Comparative Study of Femtosecond Laser-assisted LASIK and Single-step Transepithelial Photorefractive Keratectomy for Correction of Mixed Astigmatism
Sponsor study identifier
observational
39
1 country
1
Study Start
June 15, 2019
Actual (reported)Primary Completion
June 15, 2025
Actual (reported)Study Completion
June 15, 2025
Actual (reported)Mixed astigmatism is a type of refractive error in which the two principal steep and flat meridians focus the light in front and behind the retina, respectively.1 Laser vision correction (LVC) for mixed astigmatism is challenging as it involves a bitoric ablative pattern to flatten the steepest meridian and steepen the flattest one. The aim of the current study was to compare the visual and refractive outcomes of FS-LASIK versus single-step TransPRK for treatment of patients with mixed astigmatism.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 15, 2025
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 15, 2019
Actual (reported)June 15, 2025
Actual (reported)June 15, 2025
Actual (reported)March 15, 2026
Actual (reported)March 18, 2026
Actual (reported)Uncorrected distance visual acuity (UDVA)
Visual acuity measurement using Snellen's Acuity Chart converted to logMAR notation.
24 months
Corrected distance visual acuity (CDVA)
Corrected visual acuity measurement using Snellen's Acuity Chart and converted to logMAR notation.
24 months
Postoperative refraction
Manifest sphere and cylinder measured by Topcon Auto-Keratorefractometer
24 months
Patients in the FS-LASIK group underwent flap creation using the femtosecond laser WaveLight FS200® (Alcon lab, TX, USA). After flap creation, wave-front optimized stromal ablation was performed with WaveLight EX-500 (WaveLight®; Alcon Laboratories, Fort Worth, TX, USA) for mixed astigmatism correction.
Patients in the single-step TransPRK group underwent StreamLight® PRK in WaveLight EX-500 Excimer laser (WaveLight®; Alcon Laboratories, Fort Worth, TX, USA). In a single step, epithelial ablation (based on epithelial mapping) followed by stromal ablation for mixed astigmatism correction, were accomplished.
This was a retrospective comparative study conducted at Tiba eye center (private practice). The study reviewed and analyzed the records of patients with mixed astigmatism who underwent femtosecond laser-assisted LASIK (FS-LASIK group) or single-step TransPRK (TransPRK group) and completed 24 months of follow-up.
TIBA Eye Center
Asyut, Asyut Governorate, 71515, Egypt
Kaluzny BJ, Verma S, Piotrowiak-Slupska I, Kaszuba-Modrzejewska M, Rzeszewska-Zamiara J, Stachura J, Arba-Mosquera S. Three-year outcomes of mixed astigmatism correction with single-step transepithelial photorefractive keratectomy with a large ablation zone. J Cataract Refract Surg. 2021 Apr 1;47(4):450-458. doi: 10.1097/j.jcrs.0000000000000476.
Moshirfar M, Durnford K, Megerdichian A, Thomson A, Martheswaran T, West W Jr, McCabe S, Ronquillo Y, Hoopes P. Refractive Outcomes After LASIK for the Treatment of Mixed Astigmatism with the Allegretto WaveLight EX500. Ophthalmol Ther. 2022 Apr;11(2):785-795. doi: 10.1007/s40123-022-00472-4. Epub 2022 Feb 15.
39 participants (actual enrollment reported by the registry).
First Submitted
March 15, 2026
First Posted
March 18, 2026
Study Start
June 15, 2019
Actual (reported)Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
June 15, 2025
Actual (reported)Study Completion
June 15, 2025
Actual (reported)Last Updated
March 18, 2026
Record last verified: 2026-03
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Source: ClinicalTrials.gov.
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