Glyceryl Trinitrate Gel Phonophoresis on Planter Fasciiatis

NCT07480876 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/005852
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Does phonophoresis with glyceryl trinitrate gel have an effect in treatment of planter fasciitis patients?

Conditions

Planter Fasciitis

Outcome Measures

Primary Outcomes (1)

• Ultrasonography

  Patients with plantar fasciitis also typically have a thickened fascia. This change could be related to the reparative process of microtears, fiber degeneration, or edema. The average thickness of the plantar fascia in healthy individuals is between 2.2 and 3.6 mm. In patients with plantar fasciitis, it ranges from 4.6 to 6.1 mm. In general, individuals with a plantar fascia thicker than 4 mm are considered to have plantar fasciitis.

  From enrollment to the end of treatment at 5 weeks

Secondary Outcomes (4)

• visual analogue scale

  From enrollment to the end of treatment at 5 weeks

• 6-Minu Walk Test

  From enrollment to the end of treatment at 5 weeks

• Smartphone apps

  From enrollment to the end of treatment at 5 weeks

• Arabic version of modified foot function index (FFI)

  From enrollment to the end of treatment at 5 weeks

Study Arms (2)

Phonophoresis group

EXPERIMENTAL

Ultrasound will be used in addition to topical glyceryl trinitrate gel and therapeutic exercises.

Other: Phonophoresis group

ultrasound only and Therapeutic exercises

ACTIVE COMPARATOR

Other: ultrasound only and Therapeutic exercises

Interventions

Phonophoresis group OTHER

1. Patients will receive Phonophoresis with topical glyceryl trinitrate gel. Using pulsed ultrasound (2:1) with the frequency of 0.8 MHz and intensity of 1.5 W/CM for 10 minutes was dynamically administered for the patients in 10 every other day sessions. 2. Therapeutic exercises * Tibialis anterior strengthening (four sets of ten repetitions, with weights of 3 to 5 kg) * Plantar fascia stretching the patient was comfortably sitting on chair with tennis ball under his foot. Then he rolls the ball by moving his foot in forward and backward direction. * Stretching of the gastrocnemius and gastro soleus muscles by standing (standing calf stretch exercise, standing soleus muscle stretch exercise), the Achilles tendon by sitting (towel stretch exercise) , and the plantar fascia on a step (plantar fascia stretch exercise) . Patients were asked to do the exercises for four weeks, 10 times each morning and evening by counting up to 30

Phonophoresis group

ultrasound only and Therapeutic exercises OTHER

1. Patients will receive ultrasound at a frequency of 1.0 Hz and intensity of 1.2 watts/cm². Ten sessions were undertaken at a frequency of two sessions per week. 2. therapeutic exercises.

ultrasound only and Therapeutic exercises

Eligibility Criteria

• Age: 18 Years - 44 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18-44 years .
• Patients BMI 18.5 to 24.9 kg / m2.
• The diagnosis of PF appear clinically according to the history and physical - examination findings of point tenderness at or near the medial calcaneal insertion of the plantar fascia .
• Diagnosis of plantar fasciitis, with plantar fascia of more than 4 mm thickness as evaluated by ultrasonography.
• Painful symptoms lasting three months or more .

You may not qualify if:

• Diabetes mellitus, peripheral neuropathy, vasculitis and vasculopathy.
• Any pathology in ankle/foot (instability, arthritis, malignancy, acute infection, and skin disorders) .
• Pregnancy or lactation, coronary artery disease, hypertension, renal diseases and anemia .
• Atrophy/ scar or skin ulcers at the site of intervention.
• Patients with allergy to nitrates.
• Heart pacemaker use .
• Anticoagulant use and absence of coagulation disease.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo university

Cairo, Cairo Governorate, 11311, Egypt

Location

MeSH Terms

Interventions

Exercise Therapy

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Officials

• abeer Abdrahman Mohamed, Phd

  Faculty of physical therapy, Cairo university, Egypt

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fouad Sherin Fouad, PhD

CONTACT

01014411419; fouadshrin2@gmail.com

Doaa Rafat Al azab, PhD

CONTACT

01005591580; doaa.rafat@pt.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: March 14, 2026
• First Posted: March 18, 2026
• Study Start: April 30, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: March 24, 2026

Record last verified: 2026-03

Locations

EG (1)