NCT07480499

Brief Summary

TAH, being a large scale gynaecological operation, is a construction bound to cause serious postoperative pain to the patient in that the procedure will inevitably entail massive tissue dissection. Management of this postoperative pain is of utmost significance because poor analgesia may lead to delayed mobilization of the patient, long duration of hospitalization and also general increase in the morbidity of postoperative period. Traditionally, in these facilities, opioid analgesics are the most common and the most popular means of controlling postoperative pain. Nevertheless, the varied and pervasive use of opioids is largely constrained by its well-reported, dose-dependent systemic adverse effects. Nausea, vomiting, sedation, and respiratory depression are complications that severely degrade the recovery process of the patient and reduce his or her satisfaction.

Trial Health

63
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
5mo left

Started Apr 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress31%
Apr 2026Nov 2026

First Submitted

Initial submission to the registry

March 13, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 18, 2026

Completed
14 days until next milestone

Study Start

First participant enrolled

April 1, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2026

Last Updated

March 18, 2026

Status Verified

March 1, 2026

Enrollment Period

6 months

First QC Date

March 13, 2026

Last Update Submit

March 13, 2026

Conditions

Post Operative Analgesia

Keywords

post operative analgesia,erector spinae plane blockQuadratus Lumborum BlocksAbdominal Hysterectomy

Outcome Measures

Primary Outcomes (1)

  • Post Operative Pain

    Visual Analogue Score a one-dimensional indicator of pain severity. It is made up of a horizontal line that is 10 cm (100 mm) long and has two end points marked "No Pain" (0) and "Worst Possible Pain" (10). On the line, the patient marks the point that most accurately depicts their level of discomfort at 2,4,6,18 \& 24 hours post operatively.

    24 Hours

Secondary Outcomes (4)

  • Time to first Rescue Analgesia

    24 Hourse

  • Cumulative Opioid consumption

    24 Hours

  • Adverse effects

    24 Hours

  • Patient Satisfaction

    24 Hours

Study Arms (2)

Group A

ACTIVE COMPARATOR
Procedure: Erector Spinae Plane Block

Group B

ACTIVE COMPARATOR
Procedure: Quadratus Lumborum Block (QLB)

Interventions

Erector Spinae Plane BlockPROCEDURE

Ultrasound-guided erector spinae plane block at the T9-T10 level using 20 ml of 0.25% bupivacaine.

Group A
Quadratus Lumborum Block (QLB)PROCEDURE

Ultrasound-guided posterior quadratus lumborum block using 20 ml of 0.25% bupivacaine.

Group B

Eligibility Criteria

Age35 Years - 65 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients aged 35-60 years. ASA physical status I or II. Elective Total Abdominal Hysterectomy under General Anesthesia.

You may not qualify if:

  • Allergy with local anesthetics. Infection in the injection site. Coagulopathy or anticoagulant use. Morbid obesity (BMI \> 35 kg/m²).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

SKBZN CMH Muzaffarabad

Muzaffarabad, Azad Kashmir, 13100, Pakistan

Location

Related Publications (6)

  • Korgvee A, Junttila E, Koskinen H. Ultrasound-guided quadratus lumborum block for postoperative analgesia: A systematic review of case reports and randomized controlled trials. J Clin Anesth. 2021;71:110214

    BACKGROUND

  • Adhikary SD, Pruett A, Forero M, Thiruvenkatarajan V. Erector spinae plane block versusquadratus lumborum block: a meta-analysis of randomized controlled trials. Reg Anesth Pain Med. 2021;46(10):854-863.

    BACKGROUND

  • Chavan R, Goklani A, Chavan G, Mali V. Comparison of anterior quadratus lumborum block versus lumbar erector spinae plane block for postoperative analgesia in total abdominal hysterectomy: A randomized controlled study. Pain Med. 2025;26(1):12-18

    BACKGROUND

  • Baran O, Şahin A, Arar C. Comparative efficacy of erector spinae plane and quadratus lumborum blocks in managing postoperative pain for total abdominal hysterectomy: A randomized controlled trial. Medicine (Baltimore). 2024;103(43):e40313.

    BACKGROUND

  • Abdelaziz TSA, Abdou K, Salem M. Erector spinae plane block versus quadratus lumborum block for postoperative analgesia after abdominal hysterectomy: a randomized comparative study. Anaesth Pain Intensive Care. 2024;28(2):333-340.

    BACKGROUND

  • Zewdu D, Tantu T, Eanga S. Analgesic efficacy of erector spinae plane block versus transversus abdominis plane block for laparoscopic cholecystectomy: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024;11:1399253.

    BACKGROUND

Central Study Contacts

Hamid Altaf Altaf

CONTACT

+92 341 4764956hamidaltaf331@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident

Study Record Dates

First Submitted

March 13, 2026

First Posted

March 18, 2026

Study Start

April 1, 2026

Primary Completion (Estimated)

September 30, 2026

Study Completion (Estimated)

November 30, 2026

Last Updated

March 18, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)