Effects of Transversus Abdominis Plane Block on Recovery Quality and Maternal-Neonatal Outcomes After Cesarean Delivery

NCT07478692 | Completed DMC

• 1 other identifier: 202318001040
• Study Type: interventional
• Target: 83
• Locations: 1 country
• Sites: 2

Brief Summary

ltrasound-guided transversus abdominis plane (TAP) block is an emerging local anesthesia technique that effectively alleviates postoperative pain by injecting anesthetic drugs around the nerves in the abdominal wall. Compared with traditional analgesic methods, TAP blockade may have better analgesic effects and fewer side effects. However, current research on the application of TAP blockade after cesarean section is still limited. Therefore, this study will systematically evaluate its actual effectiveness in pain management after cesarean section through a prospective randomized controlled trial

Conditions

Postoperative Pain After Cesarean Section

Outcome Measures

Primary Outcomes (1)

• VAS pain scores (0-10 scale, where 0 = no pain and 10 = unbearable severe pain) at rest and during activity ( Time to first rescue analgesia requirement and number of patients and total dosage of flurbiprofen axetil used within 48 hours postoperatively;

  VAS pain scores (0-10 scale, where 0 = no pain and 10 = unbearable severe pain) at rest and during activity (coughing or turning) at 2, 6, 12, 24, and 48 hours postoperatively were recorded by anesthesiologists not involved in this study.

  5 months

Study Arms (2)

TAP Block Group

EXPERIMENTAL

The TAP block group received ultrasound-guided bilateral TAP block (20 mL of 0.375 % ropivacaine per side) during surgery and postoperative intravenous analgesia pump (formula of butorphanol 2 mg/kg + tropisetron 8 mg);

Drug: The TAP block group received ultrasound-guided bilateral TAP block (20 mL of 0.375 % ropivacaine per side) during surgery and postoperative intravenous analgesia pump (formula of butorphanol 2 mg/kg)

the control group

NO INTERVENTION

received only the same formula intravenous analgesia pump. For both groups, rescue

Interventions

The TAP block group received ultrasound-guided bilateral TAP block (20 mL of 0.375 % ropivacaine per side) during surgery and postoperative intravenous analgesia pump (formula of butorphanol 2 mg/kg) DRUG

the control group received only the same formula intravenous analgesia pump

TAP Block Group

Eligibility Criteria

• Age: 20 Years - 40 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 20-40 years, in good general health
• ASA physical status I-II
• Singleton, term (37-41 weeks) pregnancy with normal fetal development
• Planned for elective cesarean section, no labor

You may not qualify if:

• Pregnancy complications (e.g., severe preeclampsia, gestational diabetes, placental abruption)
• Major organ dysfunction (heart, liver, kidney) or psychiatric history
• Allergy to local anesthetics or any study drugs
• Prior abdominal surgery or infection that may affect block efficacy
• Coagulation disorders or current anticoagulant use
• Refusal to participate or inability to comply with follow-up

Sponsors & Collaborators

• Qing Yuan: lead

Study Sites (2)

Shandong Provincial Maternal and Child Health Care Hospital

Jinan, Shandong, 250014, China

Location

Shandong Provincial Maternal and Child Health Care Hospital

Jinan, Shandong, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Shandong Provincial Maternal and Child Health Care Hospital

Study Record Dates

• First Submitted: March 7, 2026
• First Posted: March 17, 2026
• Study Start: June 1, 2025
• Primary Completion: October 31, 2025
• Study Completion: October 31, 2025
• Last Updated: March 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)