Light Exposure, Migraine Outcomes, and Sleep Quality

NCT07476053 | Recruiting

• 1 other identifier: STUDY00023649
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.

Conditions

Migraine Headache; Sleep; Photophobia

Keywords

Migraine; Sleep; Lighting; Photophobia

Outcome Measures

Primary Outcomes (1)

• Change in Monthly Migraine Days

  Number of migraine days per 28-day period as recorded in daily electronic headache diaries. A migraine day is defined as a calendar day with a self-reported migraine meeting International Classification of Headache Disorders (ICHD-3) criteria. The primary analysis will compare the 4-week baseline period to the 4-week intervention period within participants.

  Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)

Secondary Outcomes (7)

• Change in Migraine Headache Intensity

  Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)

• Change in Migraine-Specific Quality of Life (MSQ v2.1) Score

  Baseline (Week 0), Between Baseline and Intervention (end of Week 4), and End of Intervention (Week 8).

• Change in Objective Sleep Efficiency

  Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)

• Change in Average Daily Ambient Light Intensity

  Baseline (Weeks 1-4) compared to Intervention (Weeks 5-8)

• Feasibility of Workplace Lighting Intervention

  Intervention Period (Weeks 5-8)

Study Arms (1)

Optimized Lighting Intervention

EXPERIMENTAL

All participants will complete a 4-week baseline observation period followed by a 4-week intervention period. During the baseline period, daily light exposure, sleep, and migraine characteristics will be monitored under natural conditions. During the intervention period, participants will use an optimized workplace lighting condition during working hours while continuing wearable monitoring and daily electronic surveys. Outcomes during the intervention period will be compared to baseline measurements within participants.

Other: Ambient Lighting Condition

Interventions

Ambient Lighting Condition OTHER

Application of an optimized ambient lighting condition through placement of a dimmable LED floor lamp in participants' private workspaces to create a standardized workplace lighting environment during working hours. The floor lamp emits white light with a specified spectral distribution and intensity. Participants may adjust brightness for comfort. The lighting system is used solely to modify the ambient workplace lighting environment during the 4-week intervention period.

Optimized Lighting Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Meet the International Classification of Headache Disorders, 3rd edition (2018) criteria for migraine, with or without aura or photosensitivity
• Report experiencing more than 4 headache days per month and at least three migraine attacks per month
• No other major health issues based on self-reported data
• Able to read and communicate in English
• Work in a private office space for at least six hours per day, four days per week

You may not qualify if:

• Light therapy
• Use light-altering devices (e.g., blue-blocking contact lenses or glasses)
• Traveling out of town during the participation

Sponsors & Collaborators

• Flinn Foundation: collaborator
• Arizona State University: lead

Study Sites (1)

ASU DeSmart Lab

Tempe, Arizona, 85281, United States

RECRUITING

MeSH Terms

Conditions

Migraine Disorders; Photophobia

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Nina Sharp, PhD

  Arizona State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nina Sharp, PhD

CONTACT

480-965-6536; nina.sharp@asu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Model Details: This is a single-arm, repeated-measures interventional study. All participants will complete a 4-week baseline observation period during which daily light exposure, sleep patterns, and migraine characteristics are monitored under naturalistic conditions. This will be followed by a 4-week intervention period during which an optimized workplace lighting condition will be introduced. Participants will continue wearable monitoring and daily electronic surveys throughout both phases. Outcomes during the intervention period will be compared to each participant's baseline measurements.

Study Record Dates

• First Submitted: March 8, 2026
• First Posted: March 17, 2026
• Study Start: March 24, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

US (1)