Mandibular Stretching and 4-4-8 Breathing Exercises on Autonomic Nervous System Activity

NCT07472010 | Recruiting

• 1 other identifier: NEU-2025-THESIS01
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Mandibular stretching exercises and breathing techniques may influence autonomic nervous system activity, muscle tone, and psychological state. This randomized controlled trial aims to investigate the effects of mandibular stretching exercise and the 4-4-8 breathing exercise on autonomic nervous system activity, muscle tone, and psychological parameters in healthy university students. Participants will be randomly assigned to intervention groups and evaluated before and after the intervention period.

Conditions

Muscle Tone; Psychological State; Autonomic Nervous System

Keywords

Mandibular Stretching Exercise; 4-4-8 Breathing Exercise; Breathing Techniques; Autonomic Nervous System; Muscle Tone; Psychological State

Outcome Measures

Primary Outcomes (1)

• Autonomic Nervous System Activity

  Autonomic nervous system activity will be assessed by measuring heart rate (beats per minute) using a digital pulse oximeter and blood pressure (mmHg) using an automatic blood pressure monitor. Measurements will be recorded at baseline and repeatedly after the intervention period (20, 40, 80, and 120 minutes).

  Baseline and 20, 40, 80, and 120 minutes after the intervention

Secondary Outcomes (2)

• Muscle Tone

  Baseline and 20, 40, 80, and 120 minutes after the intervention

• Psychological State

  Baseline and 20, 40, 80, and 120 minutes after the intervention

Study Arms (2)

Mandibular Stretching Exercise

EXPERIMENTAL

Participants perform mandibular stretching exercises according to the study protocol

Other: Mandibular Stretching Exercise

4-4-8 Breathing Exercise

EXPERIMENTAL

Participants perform the 4-4-8 breathing exercise according to the study protocol

Other: 4-4-8 Breathing Exercise

Interventions

Mandibular Stretching Exercise OTHER

Participants perform mandibular stretching exercises according to the study protocol

Mandibular Stretching Exercise

4-4-8 Breathing Exercise OTHER

Participants perform the 4-4-8 breathing exercise according to the study protocol.

4-4-8 Breathing Exercise

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy university students
• Age between 18 and 30 years
• Voluntary participation in the study
• Ability to understand and perform mandibular stretching exercise and 4-4-8 breathing exercise

You may not qualify if:

• History of neurological disorders
• Musculoskeletal disorders affecting the jaw, neck, or respiratory system
• Respiratory diseases
• Use of medications that may affect the autonomic nervous system
• Inability to perform the exercises required in the study

Sponsors & Collaborators

• Mehin Mammadzada: lead

Study Sites (1)

Necmettin Erbakan University

Konya, Konya, Turkey (Türkiye)

RECRUITING

Study Officials

• Neslihan Altuntaş YILMAZ, PhD

  Necmettin Erbakan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mehin Mammadzada, MSc Student

CONTACT

+905313124790; mammadzadamehin01@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be randomly assigned to intervention groups including mandibular stretching exercise, 4-4-8 breathing exercise, or control group. The effects of the interventions on autonomic nervous system activity, muscle tone, and psychological state will be evaluated.

Study Record Dates

• First Submitted: March 6, 2026
• First Posted: March 16, 2026
• Study Start: December 15, 2025
• Primary Completion: March 15, 2026
• Study Completion (Estimated): June 19, 2026
• Last Updated: March 16, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)