REHABOTICS: Physiotherapy for Hand Spasticity After Stroke Using Robotics and AR Serious Games

NCT07468149 | Completed

• 1 other identifier: REHABOTICS_02
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Rehabotics is a comprehensive rehabilitation system designed to deliver individualized upper-limb therapy for patients with motor impairments, particularly after stroke. Its core components include an exoskeletal robotic aid for assisted hand training and an interactive augmented reality platform for rehabilitation exercises and functional task practice. The system supports both treatment and assessment by enabling the monitoring of motor performance and patient progress through quantitative data. The overall aim of Rehabotics is to enhance the quality, intensity, and personalization of hand rehabilitation in clinical settings, with the potential to support remote care applications in the future.

Conditions

Stroke; Upper Extremity Dysfunction; Spasticity Post Stroke

Keywords

Robotics; Serious Games; Upper Hand Spasticity

Outcome Measures

Primary Outcomes (3)

• Box and Block Test score measured by physiotherapists

  This outcome aims to explore the therapeutic potential of Rehabotics in stroke rehabilitation, demonstrating improved hand motor function through the integration of robotics and Augmented Reality games, measured by the Box and Block Test \[BBT\] score. The BBT consists of a wooden box divided into two compartments by a partition and includes 150 blocks. During the BBT administration, the patient is instructed to move as many blocks as possible, one by one, from one compartment to the other within 60 seconds. The higher the number of blocks moved indicate better manual dexterity.

  Change from baseline to 5 weeks

• Ashworth Scale measured by physiotherapists

  This outcome aims to explore the therapeutic potential of Rehabotics in stroke rehabilitation, demonstrating improved hand motor function through the integration of robotics and Augmented Reality games, measured by Ashworth Scale \[AS\]. The AS is a key instrument for evaluating spasticity in individuals with upper extremity mobility challenges during rehabilitation. This assessment uses a scoring system from 0 to 4, where higher scores denote greater difficulty in finger movement, and lower scores indicate easier finger movement.

  Change from baseline to 5 weeks

• AROM measured by physiotherapists using gioniometry

  This outcome aims to explore the therapeutic potential of Rehabotics in stroke rehabilitation by demonstrating improvements in active finger mobility through the integration of robotics and Augmented Reality games, measured by active range of motion (AROM). In this study, AROM was assessed as Total Active Motion (TAM), which is defined as the sum of active flexion at the metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints of the finger, minus any extension deficits at these joints. Measurements were obtained using a finger goniometer, and higher TAM values indicate better active finger movement and joint mobility.

  Change from baseline to 5 weeks

Study Arms (1)

Rehabotics Physiotherapy

EXPERIMENTAL

Arm receiving Physiotherapy through the Rehabotics system

Device: Rehabotics Physiotherapy

Interventions

Rehabotics Physiotherapy DEVICE

A supervised 5-week upper-limb rehabilitation program using the Rehabotics system, delivered in 3 sessions per week, with each session lasting 30 minutes. Each session combined two components: (1) task-oriented training through an augmented reality serious-games platform using markerless hand tracking with a standard RGB camera, and (2) assisted stretching of the affected finger flexor muscles using the Active Exoskeletal Aid. The AR component included grip-specific functional tasks designed to simulate activities of daily living. The exoskeletal component provided repetitive, therapist-adjustable finger stretching through servo motor-driven movement, with programmable parameters including extension speed, maximum extension angle, and return speed.

Rehabotics Physiotherapy

Eligibility Criteria

• Age: 30 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• stroke pathology,
• Ashworth Scale ≤ 3,
• months maximum time since the incident

You may not qualify if:

• Presence of neurological pathologies that affect hand motion (Parkinson's disease)
• Musculoskeletal deficits that affect normal finger range of motion (e.g. finger fractures, joint stiffness/pain, arthritis that affect joint motion)
• Ashworth Scale \> 3,
• Over 6 months since the incident

Sponsors & Collaborators

• Pantelis Syringas: lead
• University of Ioannina: collaborator
• Physioloft, Physiotherapy Center: collaborator
• University of Peloponnese: collaborator

Study Sites (1)

Physioloft, Physiotherapy Center

Athens, Attica, 14562, Greece

Location

Related Publications (1)

• https://doi.org/10.3390/healthcare13010091

  BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Georgios Papagiannis, PhD

  Physioloft

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 9, 2026
• First Posted: March 12, 2026
• Study Start: January 1, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: March 12, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)