Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar

NCT07460869 | Active Not Recruiting

• 1 other identifier: Bothaina A. Gado
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients

Conditions

Revascularization of Immature Young Permenant Teeth

Keywords

CGF and PRF

Outcome Measures

Primary Outcomes (1)

• root growth

  change root length

  18 months

Study Arms (2)

CGF and biodentine arm

ACTIVE COMPARATOR

(control group) Which CGF and bio-dentine are applied to the immature pulp of the first permanent molar

Biological: Revascularization/Conservative management

PRF and biodentine arm

ACTIVE COMPARATOR

PRF and bio-dentine are applied on immature pulp of first permanent molar

Biological: Revascularization/Conservative management

Interventions

Revascularization/Conservative management BIOLOGICAL

Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine

CGF and biodentine arm; PRF and biodentine arm

Eligibility Criteria

• Age: 6 Years - 8 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children with immature necrotic lower fitrst permanent molar.
• No history of repeated pathosis or cellulitis.
• Patients accept the treatment modality.
• Patient-free from systemic, allergic or genetic problems.

You may not qualify if:

• Tooth mobility.
• Teeth with non-restorable crowns.
• Children with facial cellulitis
• Children with draining fistula
• Children with a history of recurrent preapical pathosis

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Faculty of Dentistry Minya University

Minya, Minya Governorate, 2422998, Egypt

Location

MeSH Terms

Interventions

Conservative Treatment

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

• Ahmed elheeny, professor of Pediatric and Com

  unaffilliaed

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer in Pediatric and Community Department, South Valley University Faculty of Dentistry

Model Details: parallel randomized controlled study

Study Record Dates

• First Submitted: February 13, 2026
• First Posted: March 10, 2026
• Study Start: January 10, 2025
• Primary Completion: July 10, 2026
• Study Completion (Estimated): July 10, 2027
• Last Updated: March 10, 2026

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: 2027
• Access Criteria: dental students and researchers in denta field

Locations

EG (1)