Mesenteric Ischemia Markers Study

NCT07460700 | Recruiting

• 1 other identifier: 35-20240303-2026
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Vascular bowel disease remains a socially significant and potentially fatal condition (if it develops into AMI), primarily due to delayed diagnosis. Blood biomarkers are theoretically ideal for early risk stratification (like troponins in myocardial infarction). However, the existing evidence base is characterized by low quality and high heterogeneity, which hinders their use in clinical practice. Therefore, there is an urgent and unmet clinical need for high-quality, methodologically rigorous research to validate biomarkers in MI. A current study (MESMARK) is to be undertaken to identify combinations of biomarkers that can reliably identify mesenteric ischemia (MI) and distinguish between non-transmural and transmural clinical relevant ischemia.

Conditions

Mesenteric Vascular Disease

Keywords

Mesenteric arteries disease; Mesenteric Ischemia; Blood biomarkers

Outcome Measures

Primary Outcomes (1)

• Increasing in the level of mesenteric ischemia (MI) markers above the reference threshold level within 1 day after enrollment in the study

  Assessment of serum markers level is intended to identify reliable serum markers or the panel of them as biomarkers for the diagnosis of MI. The endpoint is "increasing in serum marker level above the threshold reference level within 24 hours of objectively suspected MI or not". Markers with elevated above the reference threshold level will be assessed individually and in combination (as a marker panel) later to calculate their sensitivity and specificity in diagnostic of MI. These markers include intestinal fatty acid-binding protein (I-FABP), alpha-glutathione S-transferase (α-GST), ischaemia-modified albumin (IMA), D-lactate, D-dimer, adropin, hypoxia-inducible factor (HIF-1α).

  From enrollment to the 24 hours

Study Arms (1)

MA data and blood samples data

OTHER

Patients with MA lesions and suspicion of acute or chronic vascular diseases of the intestine. Patients with suspicion of AMI or CMI are to be included and blood samples are to be collected. Blood samples is the only intervention.

Diagnostic Test: Blood samples

Interventions

Blood samples DIAGNOSTIC_TEST

Blood samples as diagnostic tests are the only intervention in the trial

MA data and blood samples data

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years or older, all sex
• Initial decision, the presence of angio-visualisation of the MA and suspicion of mesenteric arteries diseases
• Patient's consent to participate in the study
• No pregnancy, no history of major operations on MA, the gastrointestinal tract and digestive organs (except appendectomy, endoscopic polypectomy).

You may not qualify if:

• Consent declined by patient or relatives

Sponsors & Collaborators

• Belarusian State Medical University: lead

Study Sites (1)

Belarusian State Medical University

Minsk, Belarus

RECRUITING

MeSH Terms

Conditions

Mesenteric Ischemia

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Peritoneal Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Hleb But-Husaim, PhD

CONTACT

+375256139407; dr.buthusaim@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of the Department of Surgery and Endoscopy BSMU, MD, PhD

Model Details: Blood samples is to be collected from study subjects

Study Record Dates

• First Submitted: February 27, 2026
• First Posted: March 10, 2026
• Study Start: December 22, 2025
• Primary Completion (Estimated): August 12, 2026
• Study Completion (Estimated): December 12, 2026
• Last Updated: March 10, 2026

Record last verified: 2026-03

Locations

BE (1)