NCT07460583

Brief Summary

AI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
5mo left

Started Aug 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 27, 2026

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 10, 2026

Completed
6 months until next milestone

Study Start

First participant enrolled

August 28, 2026

Expected
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2027

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2027

Last Updated

May 5, 2026

Status Verified

April 1, 2026

Enrollment Period

5 months

First QC Date

February 27, 2026

Last Update Submit

April 30, 2026

Conditions

Coronary Atherosclerosis Due to Calcified Coronary Lesion

Outcome Measures

Primary Outcomes (2)

  • Prevalence of Coronary Atherosclerosis

    The primary outcome is to determine the prevalence of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

    At CCTA assessment

  • Coronary Atherosclerosis Characteristics

    Determine the characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

    At CCTA Assessment

Secondary Outcomes (1)

  • Plaque Burden

    Day of CCTA and biomarker collection

Study Arms (1)

Athletes

EXPERIMENTAL

This arm will have answer a questionnaire, have a physical exam performed as well as a Coronary CTA and labs completed. The Coronary CTA images will be analyzed using AI-software to assess plaque quantification and an ischemia analysis.

Device: Coronary CTA

Interventions

Coronary CTADEVICE

The Coronary CTA will be performed for each participant. These images will be analyzed using AI-software to assess plaque quantification and an ischemia analysis, if necessary.

Athletes

Eligibility Criteria

Age30 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Former professional or collegiate high-intensity athletes (e.g., NFL alumni, Division I athletes, or equivalent competitive-level participants).
  • Age ≥30 years

You may not qualify if:

  • eGFR \<40 mL/min/1.73 m²
  • Known iodinated contrast allergy
  • Weight \>450 lbs. (scanner table limit)
  • Inability to hold breath \>10 seconds
  • Uncontrolled arrhythmia
  • Contraindication to beta-blocker, Calcium Channel Blockers and nitroglycerin
  • Taking part in another research study that has not given their permission to participate in this one
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Baylor Scott & White The Heart Hospital- Plano

Plano, Texas, 75093, United States

Location

Central Study Contacts

Bonnie Ostergren

CONTACT

469-814-4181bonnie.ostergren@bswhealth.org

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 27, 2026

First Posted

March 10, 2026

Study Start (Estimated)

August 28, 2026

Primary Completion (Estimated)

January 31, 2027

Study Completion (Estimated)

January 31, 2027

Last Updated

May 5, 2026

Record last verified: 2026-04

Locations

US(1)