NCT07460050

Brief Summary

Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention. So, it provides a better visiblity of surgical filed to the surgeons.This RCT compares propofol infusion vs isoflurane inhalation for inducing controlled hypotension during endoscopic sinus surgery. The goal is to assess which agent better controls blood pressure, improves surgical field visibility, and impacts recovery. It likely measures outcomes like hemodynamics, bleeding, and surgeon satisfaction.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
136

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2026

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

March 4, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 10, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2026

Completed
Last Updated

March 10, 2026

Status Verified

March 1, 2026

Enrollment Period

5 months

First QC Date

March 4, 2026

Last Update Submit

March 4, 2026

Conditions

Controlled Hypotension for Nasal Surgeries

Keywords

Controlled hypotentionPropofol infusionEndoscopic sinus surgeryIsoflurane inhalation

Outcome Measures

Primary Outcomes (2)

  • Surgical field visibility

    The surgical field visibility time frame for propofol vs isoflurane during endoscopic sinus surgery assessed intraoperatively is usually 30-60mins postinduction

  • Surgical field visibility

    The surgical field visibility time frame assessed intraoperatively during endoscopic sinus surgery is usually 30- 60 mins post induction

Study Arms (2)

Patient receiving Propofol infusion for controlled hypotention during surgery under general anaes

EXPERIMENTAL

Intravenous propfol infusion (starting 12mg/kg/hr) adminitration intraoperatively as sedative for controlled hypotension during endoscopic sinus surgery

Drug: Propofol

Isoflurane inhalation for controlled hypotension during surgery under general anaesthesia

ACTIVE COMPARATOR

Isoflurane inhalation (1-2% end tidal) given intraoperativley as sedative for controlled hypotension during eendoscopic sinus surgery

Drug: Isoflurane

Interventions

PropofolDRUG

Intravenous propofol infusion (starting dose 12mg/kg/hr and titrated accordingly) given to patients as sedative undergoing endscopic sinus surgery for hemodynamic stability

Patient receiving Propofol infusion for controlled hypotention during surgery under general anaes
IsofluraneDRUG

Isoflurane inhalation (1-2% end tidal) used in patients as sedative undergoing endoscopic sinus surgery for hemodynamic stability

Isoflurane inhalation for controlled hypotension during surgery under general anaesthesia

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Either male/female Age 18-65 Patients undergoing endoscopic sinus surgery as per the operational definition

You may not qualify if:

  • Patients with cardiovascular disease Patients with pregnancy Patients with coagulopathy Patients on beta blockers or calcium channel blockers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hayatabad Medical Complex, Peshawar

Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan

Location

MeSH Terms

Interventions

PropofolIsoflurane

Intervention Hierarchy (Ancestors)

PhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsMethyl EthersEthers

Study Officials

  • Dr. Laiba Khalid, Postgraduate trainee

    Hayat Abad Medical Complex, Peshawar

    STUDY CHAIR

Central Study Contacts

Dr. Laiba Khalid, Trainee Medical Officer

CONTACT

+923320031941kgmcite15@gmail.com

Dr. Laiba Khalid, Trainee Medical Officer

CONTACT

03320031941kgmcite15@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

March 4, 2026

First Posted

March 10, 2026

Study Start

March 1, 2026

Primary Completion

August 1, 2026

Study Completion

August 1, 2026

Last Updated

March 10, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared due to patient confidentiality and institutional policies

Locations

PA(1)