NCT07458867|Not Yet RecruitingDMC
International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes
IMPEL
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IMPEL
Sponsor study identifier
observational
500
0 countries
N/A
Study Start
July 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
July 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies. IMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 4, 2026
Actual (reported)March 9, 2026
Actual (reported)July 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
July 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
30 day morbidity
Occurrence of postoperative complications within 30 days of hospital day zero (baseline) or date of surgery, graded using the Clavien-Dindo classification.
From hospital admission date or date of surgery (whichever is later) to 30 days later.
30 day mortality
30 days
Stoma creation
From hospital day 0 (baseline) to 90 days.
Stoma reversal
from hospital discharge (baseline) to 6 months
Length of hospital stay
From hospital day 0 (baseline) to dischagre in a time frame of 90 days.
Association of admitting specialty and on-call model with clinical outcomes and care processes.
From index admission (day 0) to 30 days (for 30-day outcomes).
All enrolled participants with mechanical large-bowel obstruction managed according to local standard-of-care practices.
The study population comprises consecutive adults (≥18 years) admitted to participating acute care hospitals with a diagnosis of mechanical large-bowel obstruction, with or without associated large-bowel perforation attributable to obstruction. Patients are enrolled irrespective of management strategy (operative or non-operative), and care is delivered according to local standard practice. Participating sites include international hospitals providing emergency general surgery care. Enrollment occurs during a predefined 90-day consecutive inclusion period selected by each site within a global six-month study window, with follow-up through 30 days for postoperative outcomes and through 6 months for stoma-related outcomes.
Gary A Bass, MD, PhD
University of Pennsylvania
First Submitted
February 4, 2026
First Posted
March 9, 2026
Study Start
July 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
Contact the study team to confirm eligibility.
June 30, 2027
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
July 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
March 9, 2026
Record last verified: 2026-03
De-identified individual participant data (IPD) underlying published analyses from this study may be made available to qualified researchers on reasonable request, subject to approval by the IMPEL Steering Committee and compliance with applicable data protection regulations. Shared IPD will be limited to the minimum dataset necessary to address the approved research question and will exclude all direct identifiers. Data sharing will occur only after publication of the primary study results and under a data use agreement specifying the scope of use, authorship expectations, and data security requirements.
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Source: ClinicalTrials.gov.
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