Prehabilitation to Enhance Preoperative Function in Elderly Undergoing Abdominal Malignancy Surgery

NCT07456943 | Not Yet Recruiting DMC

• 1 other identifier: 1145/2568 (IRB1)
• Study Type: observational
• Target: 110
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to evaluate the effectiveness of the multimodal prehabilitation program at the Siriraj Integrated Preoperative and Prehabilitation Center (SiPAP) on improving preoperative walking capacity and functional status in patients undergoing elective intraabdominal cancer surgery. The main question it aims to answer is: \- Does the prehabilitation program lead to a significant change in 6-minute walk distance (6MWD) at preoperative admission as compared to at baseline assessment? Participants will receive the structured multimodal prehabilitation program, which represents the standard of care for patients in the ERAS protocol at the study site. Outcomes will be measured at preoperative admission and at 1 and 3 months after surgery.

Conditions

Prehabilitation; Functional Capacity

Keywords

Prehabilitation; Functional capacity; Preoperative care; Abdominal cancer surgery

Outcome Measures

Primary Outcomes (1)

• Six-minute walk distance (6MWD)

  A six-minute walk test will be performed on a standardized 30-meter indoor track following American Thoracic Society guidelines. Distance that participants can walk in 6 minutes will be record as six-minute walk distance (6MWD)

  Preoperative period and postoperative period (1 and 3 months)

Secondary Outcomes (3)

• Dominant handgrip strength

  Preoperative period and postoperative period (1 and 3 months)

• Lower limb strength, balance, and functional mobility

  Preoperative period and postoperative period (1 and 3 months)

• Functional capacity

  Preoperative period and postoperative period (1 and 3 months)

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients who enroll to Enhanced Recovery After Surgery (ERAS) program, Siriraj Hospital and referred to the SiPAP program.

You may qualify if:

• Diagnosed with intraabdominal malignancy (e.g., colorectal, esophageal, gastric, pancreatic, hepatic, biliary tract, urinary bladder, or endometrial malignancies).
• Schedules for elective major surgery and formally enrollment in the ERAS program at Siriraj Hospital. (at Siriraj Hospital, patients scheduled for pre-specific elective major surgeries are enrolled into the ERAS program as individual hospital protocols for each ERAS module. All patients are informed about the ERAS program by their surgical team.)
• Referred to the SiPAP center for prehabilitation in accordance with the ERAS preoperative protocol, with a minimum preoperative time of 14 days before the scheduled surgery date.
• Able to understand the study protocol and provide written informed consent.

You may not qualify if:

• Have emergency surgery
• Reschedule the surgery for an earlier date, allowing less than 14 days for prehabilitation.
• Severe cardiopulmonary or musculoskeletal conditions that contraindicate exercise (e.g., unstable angina, decompensated heart failure, severe COPD, or orthopedic disability).
• Cognitive impairment or psychiatric illness precluding participation in prehabilitation.
• Refusal to participate.
• Inability to comply with the protocol.

Sponsors & Collaborators

• Siriraj Hospital: lead

Related Publications (10)

• Bohannon RW, Crouch R. Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: a systematic review. J Eval Clin Pract. 2017 Apr;23(2):377-381. doi: 10.1111/jep.12629. Epub 2016 Sep 4.

  PMID: 27592691 BACKGROUND

• Tew GA, Bedford R, Carr E, Durrand JW, Gray J, Hackett R, Lloyd S, Peacock S, Taylor S, Yates D, Danjoux G. Community-based prehabilitation before elective major surgery: the PREP-WELL quality improvement project. BMJ Open Qual. 2020 Mar;9(1):e000898. doi: 10.1136/bmjoq-2019-000898.

  PMID: 32213551 BACKGROUND

• Moran J, Guinan E, McCormick P, Larkin J, Mockler D, Hussey J, Moriarty J, Wilson F. The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis. Surgery. 2016 Nov;160(5):1189-1201. doi: 10.1016/j.surg.2016.05.014. Epub 2016 Jul 8.

  PMID: 27397681 BACKGROUND

• Thomas G, Tahir MR, Bongers BC, Kallen VL, Slooter GD, van Meeteren NL. Prehabilitation before major intra-abdominal cancer surgery: A systematic review of randomised controlled trials. Eur J Anaesthesiol. 2019 Dec;36(12):933-945. doi: 10.1097/EJA.0000000000001030.

  PMID: 31188152 BACKGROUND

• Barberan-Garcia A, Ubre M, Roca J, Lacy AM, Burgos F, Risco R, Momblan D, Balust J, Blanco I, Martinez-Palli G. Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery: A Randomized Blinded Controlled Trial. Ann Surg. 2018 Jan;267(1):50-56. doi: 10.1097/SLA.0000000000002293.

  PMID: 28489682 BACKGROUND

• Santa Mina D, Clarke H, Ritvo P, Leung YW, Matthew AG, Katz J, Trachtenberg J, Alibhai SM. Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis. Physiotherapy. 2014 Sep;100(3):196-207. doi: 10.1016/j.physio.2013.08.008. Epub 2013 Nov 13.

  PMID: 24439570 BACKGROUND

• Li C, Carli F, Lee L, Charlebois P, Stein B, Liberman AS, Kaneva P, Augustin B, Wongyingsinn M, Gamsa A, Kim DJ, Vassiliou MC, Feldman LS. Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study. Surg Endosc. 2013 Apr;27(4):1072-82. doi: 10.1007/s00464-012-2560-5. Epub 2012 Oct 9.

  PMID: 23052535 BACKGROUND

• Mayo NE, Feldman L, Scott S, Zavorsky G, Kim DJ, Charlebois P, Stein B, Carli F. Impact of preoperative change in physical function on postoperative recovery: argument supporting prehabilitation for colorectal surgery. Surgery. 2011 Sep;150(3):505-14. doi: 10.1016/j.surg.2011.07.045.

  PMID: 21878237 BACKGROUND

• Hughes MJ, Hackney RJ, Lamb PJ, Wigmore SJ, Christopher Deans DA, Skipworth RJE. Prehabilitation Before Major Abdominal Surgery: A Systematic Review and Meta-analysis. World J Surg. 2019 Jul;43(7):1661-1668. doi: 10.1007/s00268-019-04950-y.

  PMID: 30788536 BACKGROUND

• Carli F, Scheede-Bergdahl C. Prehabilitation to enhance perioperative care. Anesthesiol Clin. 2015 Mar;33(1):17-33. doi: 10.1016/j.anclin.2014.11.002. Epub 2015 Jan 9.

  PMID: 25701926 BACKGROUND

Study Officials

• Wariya Vongchaiudomchoke, MD, MSc

  Mahidol University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wariya Vongchaiudomchoke, MD, MSc

CONTACT

+66 85-920-9495; wariya.von@mahidol.ac.th

Mingkwan Wongyingsinn, MD

CONTACT

+66 81-915-3320; Mingkwan.won@mahidol.ac.th

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 2, 2026
• First Posted: March 9, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: April 28, 2026

Record last verified: 2026-04