Prospective Evaluation of Upright Versus Supine CT Myelography of the Lumbar Spine
1 other identifier
interventional
20
1 country
1
Brief Summary
The purpose of this prospective study is to compare the diagnostic utility of standing (upright, weight-bearing) CT myelography with standard supine CT myelography for the evaluation of lumbar central canal and neural foraminal stenoses. This study aims to determine whether upright positioning provides additional diagnostic information in patients unable to undergo MRI, with the goal of improving assessment and management of degenerative lumbar spine disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2026
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 13, 2025
CompletedFirst Posted
Study publicly available on registry
March 6, 2026
CompletedStudy Start
First participant enrolled
June 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
June 8, 2026
November 1, 2025
6 months
November 13, 2025
June 3, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Does upright CT imaging change management plans for patients with lumbar spinal stenosis
To determine whether upright CT imaging changes the management plan (yes or no) for patients with lumbar spinal stenosis.
1 week
Secondary Outcomes (6)
Spine measurements
1 day
Severity grading of central canal stenosis
1 day
Severity grading of neural foraminal stenosis
1 day
Presence or absence of nerve root compression
1 day
Presence or absence of disc bulges
1 day
- +1 more secondary outcomes
Study Arms (1)
Upright and Supine CT Myelography
OTHERUpright and Supine CT Myelography
Interventions
Upright CT Myelography
Eligibility Criteria
You may qualify if:
- Age ≥ 18 years
- Outpatient status
- Scheduled for routine supine CT myelography
You may not qualify if:
- Inpatient status
- Prior lumbar spine surgical intervention or presence of metallic lumbar spinal hardware (thoracic or cervical spinal procedures are permitted)
- History of osseous metastatic disease involving the lumbar spine
- Acute traumatic injury involving the lumbar spine
- Pregnancy
- Participant body habitus exceeding the scanner's safe operational limits (e.g., gantry/bore size clearance, table weight capacity) as defined by the device manufacturer.
- Inability to tolerate CT scanning (e.g., severe pain, unable to stand independently for an extended period)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, Assistant Professor
Study Record Dates
First Submitted
November 13, 2025
First Posted
March 6, 2026
Study Start
June 1, 2026
Primary Completion (Estimated)
December 1, 2026
Study Completion (Estimated)
December 1, 2026
Last Updated
June 8, 2026
Record last verified: 2025-11