The Effects of Brief Periods of Exercise on Blood Pressure

NCT07453550 | Recruiting

• 1 other identifier: 25-12-505
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.

Conditions

Hypertension (HTN); Pre Hypertension

Keywords

isometric exericse

Outcome Measures

Primary Outcomes (1)

• 24 h blood pressure

  The average, peak and variations of 24 h SBP and DBP, daytime SBP and DBP, night time SBP and DBP will be measured before and after the intervention.

  From the enrollment to the end of the study at six weeks

Secondary Outcomes (2)

• endothelial function

  at baseline (Day 1) and Week 6

• arterial stiffness

  at baseline (Day 1) and week 6

Study Arms (3)

Non-Ex control group

NO INTERVENTION

Clustered Ex Condition

ACTIVE COMPARATOR

Behavioral: wall-squat-tradition

Scattered Ex Condition

EXPERIMENTAL

Behavioral: wall-squat

Interventions

wall-squat BEHAVIORAL

the experimental group will complete the four sets of wall-squats at four different times across the day: morning, noon, afternoon, night.

Scattered Ex Condition

wall-squat-tradition BEHAVIORAL

The other exercise group will do 4 sets of wall squat in a continuous way.

Clustered Ex Condition

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• yrs.
• hour average BP \>110/70 mmHg, but \< 160 systolic blood pressure
• Able to provide informed consent

You may not qualify if:

• Currently taking anti-hypertensive medication smokers and alcohol drinkers Inability to undertake exercise intervention (resistance and isometric exercise)
• Current medical history of any of the following:
• hyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel
• Previous medication history of any of the following:
• hyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel

Sponsors & Collaborators

• University of Hartford: lead

Study Sites (1)

University of Hartford

West Hartford, Connecticut, 06117, United States

RECRUITING

MeSH Terms

Conditions

Hypertension; Prehypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Jinghui Yang, PT, MPT, PhD

CONTACT

347-429-0843; jiyang@hartford.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: For the acute study, a cross-over design will be used to allow each participant to go through both conditions. For the long-term study, a randomized controlled study design will be used.

Study Record Dates

• First Submitted: February 15, 2026
• First Posted: March 6, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: May 1, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: The IPD information will be available 1-1-2027 for six months.

Locations

US (1)