NCT07453524

Brief Summary

The goal of this study is to ask chronic pain patients their preferences regarding which side effects of pain medications are least acceptable in relation to their pain relief benefits. This information may help in the selection of improved treatment options in the future.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable chronic-pain

Timeline
20mo left

Started Mar 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress11%
Mar 2026Dec 2027

First Submitted

Initial submission to the registry

August 18, 2025

Completed
7 months until next milestone

First Posted

Study publicly available on registry

March 6, 2026

Completed
9 days until next milestone

Study Start

First participant enrolled

March 15, 2026

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

March 20, 2026

Status Verified

March 1, 2026

Enrollment Period

1.4 years

First QC Date

August 18, 2025

Last Update Submit

March 17, 2026

Conditions

Chronic Pain

Outcome Measures

Primary Outcomes (1)

  • Chronic pain patient preferences of pain medications regarding pain relief relative to the side effects using numeric rating scales (adaptation of the outcome prioritization tool).

    Using numeric rating scales from 0 to 10 (adaptation of the outcome prioritization tool) to assess patient perceived importance of analgesic effect relative to not having the following side effects: fatigue, drowsiness (sleepiness), dizziness, difficulty concentrating, nausea, constipation (difficulty passing stools), dry mouth, unintentional weight gain, addiction (medication craving). Higher scores mean the specific outcome is a higher priority for the participant.

    Single measure at a time selected by the participant within the study period (up to 15 months).

Secondary Outcomes (11)

  • Analgesic side effect burden measured by numeric rating scales (NRS)

    Single measure at a time selected by the participant within the study period (up to 15 months).

  • Patient pain levels in the last 24 hours and pain body location and its impact on functioning measured by the Brief Pain Inventory short form (BPI-SF).

    Single measure at a time selected by the participant within the study period (up to 15 months).

  • Overall pain levels in the past 7 days measured by a numeric rating scale.

    Single measure at a time selected by the participant within the study period (up to 15 months).

  • Overall sleep quality in the past 7 days measured by a numeric rating scale.

    Single measure at a time selected by the participant within the study period (up to 15 months).

  • Satisfaction of pain treatment will be assessed by select items from the PTSS

    Single measure at a time selected by the participant within the study period (up to 15 months).

  • +6 more secondary outcomes

Study Arms (1)

Chronic pain patients

OTHER
Other: Patient questionnaire

Interventions

Patient questionnaireOTHER

Online patient questionnaire that assesses multiple aspects such as current analgesic use, side effect burden, treatment satisfaction and patient preferences.

Chronic pain patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Aged over 18 years.
  • Being treated with pain medication.
  • (Chronic-)Pain for at least 3 months.
  • Capacity to understand and provide an informed consent form.

You may not qualify if:

  • Insufficient French or English language skills.
  • Epilepsy treated by an anti-epileptic.
  • Alzheimer's disease.
  • Parkinson's disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Chronic Pain

Interventions

Patient Health Questionnaire

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Surveys and QuestionnairesData CollectionEpidemiologic MethodsInvestigative TechniquesPsychological TestsBehavioral Disciplines and ActivitiesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 18, 2025

First Posted

March 6, 2026

Study Start

March 15, 2026

Primary Completion (Estimated)

July 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

March 20, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share