Selective Versus Contiguous Connective Tissue Grafts in the Modified Tunnel Technique

NCT07453147 | Recruiting

• 1 other identifier: B7072025000052
• Study Type: interventional
• Target: 32
• Locations: 2 countries
• Sites: 2

Brief Summary

The goal of this study is to evaluate how effective a gum grafting procedure is in treating gum recession that affects several teeth. Gum recession happens when the gum tissue pulls away from the tooth, exposing the roots. The study will look at how the treatment improves gum health, appearance, and function. A total of 32 patients will take part in the study. All patients will be treated with a modified coronally advanced tunnel. For half of them of contiguous graft will be used, for the other half a segmented graft. Data collected will include medical history, dental and aesthetic information, clinical measurements, and a digital scan of the mouth. The study will include the following steps: Before the procedure: You will have a clinical and X-ray examination to determine how much your gums have receded. A digital impression of your teeth will also be taken. Surgical procedure: You will receive a gum graft to cover the exposed roots. This involves moving gum tissue, often taken from the roof of your mouth, to the affected areas. After the procedure: You will have several follow-up visits over a few months to check your healing and the results of the treatment. Study timeline: The surgery will be done once. Follow-up visits will take place 1, 3, 6, and 12 months after the surgery. The total duration of the study is about 12 months.

Conditions

Gum Recession

Keywords

Gum recession; Recession treatment; Tunnel technique; Connective tissue graft; Gingival recession

Outcome Measures

Primary Outcomes (1)

• Digital complete root coverage

  defined as the presence/absence of complete coverage of the recession at the mid-buccal aspect. It will be evaluated by taking the CEJ as a reference line, at the different timepoints, analysed digitally using the digital impression

  3, 6 and 12 months

Secondary Outcomes (11)

• Complete Root Coverage

  3, 6 and 12 months

• Mean Root Coverage

  3, 6 and 12 months

• Keratinized Tissue Height

  3, 6 and 12 months

• Recession reduction

  3, 6 and 12 months

• Dental hypersensitivity

  3, 6 and 12 months

Study Arms (2)

Selective/Segmented graft

EXPERIMENTAL

In this group a segmented CTG will be used

Procedure: Selective/Segmented graft

Continuous graft

ACTIVE COMPARATOR

In this group a continuous CTG will be used

Procedure: Continuous graft

Interventions

Selective/Segmented graft PROCEDURE

In this group a segmented CTG will be used

Selective/Segmented graft

Continuous graft PROCEDURE

In this group a continuous CTG will be used

Continuous graft

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA I or ASA II
• Good periodontal health
• Able to undergo oral surgery
• Must be 18 years old and older
• No smoking
• At least two teeth in the same sector in the maxilla and the right and left mandible (except in the mandibular incisive sector), of which at least 2 are contiguous, with vestibular gingival recessions of type RT 1 of 1-5mm (Cairo et al. 2011)
• An identifiable or restorable cemento-enamel junction (CEJ), with or without the presence of a non-carious cervical lesion (Pini-Prato et al. 2010)
• Plaque index (O'Leary 1972) and bleeding index (Ainamo et al. 1975) scores of less than 20%
• Able to give informed consent and have signed the consent forms

You may not qualify if:

• Teeth showing recession associated with a carious lesion, restoration or cervical prosthesis involving CEJ
• Teeth with recession depth \>5mm
• Molars with recessions will be treated but will not be taken into account for the measurements
• Teeth with recession that have already undergone periodontal surgery
• Presence of severe tooth malposition, rotation or significant version of the tooth
• Smoker and ex-smoker
• Patient suffering from a disease affecting the periodontium
• Patient with clinical signs of active periodontitis
• Known pregnancy in progress or breastfeeding
• Contraindication to surgery
• Conditions or circumstances which would prevent completion of study participation or interfere with analysis of study results, such as history of no-compliance or unreliability
• Patients deprived of their liberty or under legal protection

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Liege: lead
• 26K Center for Clinical Research: collaborator

Study Sites (2)

CHU de Liège

Liège, Liège, 4000, Belgium

RECRUITING

26K Center for clinical research

Paris, 75116, France

NOT YET RECRUITING

MeSH Terms

Conditions

Gingival Recession

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: December 14, 2025
• First Posted: March 5, 2026
• Study Start: September 1, 2025
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: March 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1); FR (1)