NCT07452159|Not Yet Recruiting
Diabetes In Asians at Risk in Youth
DIARY
Diabetes in Asians at Risk in Youth
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DIARY
Diabetes in Asians at Risk in Youth
Sponsor study identifier
Secondary identifiers
OTHER · Tanoto
observational
3,000
0 countries
N/A
Study Start
March 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1, 2025
Actual (reported)March 5, 2026
Actual (reported)March 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Diagnosis of diabetes
Fasting glucose \>/=7mmol/l or 2-hour glucose \>/=11.1 mmol/l on oral glucose tolerance test or HbA1c \>/=7%.
Baseline
Diagnosis of pre-diabetes
Baseline
Not previously known to have diabetes
Following overnight fasting for 8 hours
Body Mass Index, Waist-Hip ratio, Blood pressure
Islandwide across Singapore
Zahalka SJ, Galindo RJ, Shah VN, Low Wang CC. Continuous Glucose Monitoring for Prediabetes: What Are the Best Metrics? J Diabetes Sci Technol. 2024 Jul;18(4):835-846. doi: 10.1177/19322968241242487. Epub 2024 Apr 17.
Deurenberg P, Deurenberg-Yap M, Guricci S. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev. 2002 Aug;3(3):141-6. doi: 10.1046/j.1467-789x.2002.00065.x.
Serum, EDTA whole blood.
Daphne SL Gardner, BA, BMBCh(Oxon), MRCP (UK)
Singapore Health
First Submitted
December 1, 2025
First Posted
March 5, 2026
Study Start
March 18, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
January 2, 2029
EstimatedIntermittent Versus Continuous Glucose Monitoring in Intensive Care Unit
Body composition analysis
Handgrip strength measured using Jamar Dynanometer
Use of Retrospective continuous glucose monitoring sensor (Freestyle Libre Pro IQ)
Including written food records and photographs for all food and drink intake
Retrieval of sociodemographic details, family history of diabetes and comorbid conditions, information on dietary intake, physical activity levels, and health seeking behaviour. This includes average daily step count for 7/30 days.
Form to feedback on any sensor skin reactions
This will involve a highly curated list of information to be retrieved from Facebook, Instagram and TikTok to enable AI-led sociobehavioural profiling. This will not retrieve any information on posts, photos, likes, comments, reactions or any item that will express intent.
Whole blood sample will be retrieved and stored before being sent for whole genome sequencing at a later stage.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Kuang M, Lu S, Yang R, Chen H, Zhang S, Sheng G, Zou Y. Association of predicted fat mass and lean body mass with diabetes: a longitudinal cohort study in an Asian population. Front Nutr. 2023 May 9;10:1093438. doi: 10.3389/fnut.2023.1093438. eCollection 2023.
Yeung RO, Zhang Y, Luk A, Yang W, Sobrepena L, Yoon KH, Aravind SR, Sheu W, Nguyen TK, Ozaki R, Deerochanawong C, Tsang CC, Chan WB, Hong EG, Do TQ, Cheung Y, Brown N, Goh SY, Ma RC, Mukhopadhyay M, Ojha AK, Chakraborty S, Kong AP, Lau W, Jia W, Li W, Guo X, Bian R, Weng J, Ji L, Reyes-dela Rosa M, Toledo RM, Himathongkam T, Yoo SJ, Chow CC, Ho LL, Chuang LM, Tutino G, Tong PC, So WY, Wolthers T, Ko G, Lyubomirsky G, Chan JC. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort. Lancet Diabetes Endocrinol. 2014 Dec;2(12):935-43. doi: 10.1016/S2213-8587(14)70137-8. Epub 2014 Jul 28.
Rama Chandran S, Sng GGR, Wong CYH, Ang WM, Gardner D. Continuous Glucose Monitoring Metrics in Asians Without Diabetes: Differentiating Prediabetes From Normoglycemia. J Diabetes Sci Technol. 2025 Oct 21:19322968251384682. doi: 10.1177/19322968251384682. Online ahead of print.
Tan JK, Salim NNM, Lim GH, Chia SY, Thumboo J, Bee YM. Trends in diabetes-related complications in Singapore, 2013-2020: A registry-based study. PLoS One. 2022 Oct 11;17(10):e0275920. doi: 10.1371/journal.pone.0275920. eCollection 2022.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
March 5, 2026
Record last verified: 2026-02
This is an observational study, only aggregated data will be provided. In addition, there is a part of the study that retrieves information social media activity. There is a potential that individual level data can lead to sensitive personal information being revealed.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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