The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods

NCT07451405 | Recruiting

• 1 other identifier: 20251211001
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

High frequency chest wall oscillation (HFCWO) is currently one of the most common and widespread mechanical airway clearance techniques (ACTs) in clinical practice in China. As an external airway oscillation technique, it has been proven in previous clinical practices that it can help clear secretions by vibrating the chest wall, loosening the secretions adhering to the airway walls and promoting ciliary movement, thereby improving lung ventilation and re-expansion. However, there are still some groups of patients for whom this technique is not suitable in clinical practice, such as those who are uncomfortable with the oscillation, have damaged skin on the chest and back, have unstable rib fractures, or have poorly positioned tracheostomy tubes. In recent years, integrating multiple techniques into a single treatment has become a trend. Among them, oscillation and lung expansion (OLE) combines continuous positive airway pressure (CPAP), continuous high-frequency oscillation (CHFO), and nebulization, which can effectively clear airway secretions and promote lung re-expansion. Currently, only a few studies have confirmed that OLE has a positive impact on improving respiratory function in patients with acute respiratory failure, severe burns, and after lung surgery. This study aims to further compare the effects of the above two mechanical ACTs on improving lung ventilation and re-expansion by electrical impedance tomography (EIT), and optimize the clinical practice of physical therapists.

Conditions

Atelectasis

Keywords

oscillation and lung expansion; high frequency chest wall; electrical impedance tomography; Atelectasis

Outcome Measures

Primary Outcomes (1)

• Change in Atelectatic Lung Area on Chest CT

  Atelectatic lung area will be quantified on chest computed tomography (CT) images by a blinded radiologist using imaging analysis software. The primary outcome is the change in atelectatic lung area from baseline to 10 days post-treatment. The unit of the measures is Square centimeters (cm²)

  Baseline and 10 days post-treatment

Secondary Outcomes (6)

• Ventilation distribution on Electrical impedance tomography (EIT) evaluation

  at admission and 3days/7days/10 days after treatment

• Lung Ultrasound score(LUS)

  at admission and 10 days after treatment

• Oxygenation index

  at admission and 10 days after treatment

• the score on Modified Borg dyspnea scale

  at admission and 10 days after treatment

• The Clinical Pulmonary Infection Score

  from enrollment to 2 weeks after the treatment

Study Arms (2)

Coventional therapy group

PLACEBO COMPARATOR

This group conducted casual treatment and airway clearance (except oscillation an lung expansion therapy)

Other: High frequency chest wall oscillation or other airway clearance therapy

OLE group

EXPERIMENTAL

This group conducted casual treatment and oscillation an lung expansion on daily therapy

Other: High frequency chest wall oscillation or other airway clearance therapy; Other: Oscillation and lung expansion

Interventions

High frequency chest wall oscillation or other airway clearance therapy OTHER

High frequency chest wall oscillation (HFCWO) is an external airway oscillation technique, it has been proven in previous clinical practices that it can help clear secretions by vibrating the chest wall, loosening the secretions adhering to the airway walls and promoting ciliary movement, thereby improving lung ventilation and re-expansion. We will give the patients HFCWO twice a day and each time we will give them 15HZ as frequency and 20mins as time. Other therapies are postural drainage, manual vibration...

Coventional therapy group; OLE group

Oscillation and lung expansion OTHER

oscillation and lung expansion (OLE) combines continuous positive airway pressure (CPAP), continuous high-frequency oscillation (CHFO), and nebulization, which can effectively clear airway secretions and promote lung re-expansion. The OLE will be given to the patients twice a day as well, and each time 10mins therapy with 2.5mins CPAP and 2.5mins CHFO cirsularly.

OLE group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years old
• The following characteristics of high mucus secretion in the airway occur along with pulmonary infection: coughing up a large amount of white sticky phlegm, yellow phlegm or yellow purulent phlegm; Phlegm sounds can be heard in the lungs. The frequency of sputum aspiration is higher than once every 4 hours
• Tracheotomy time ≥7 days
• Vital signs are stable.

You may not qualify if:

• Hemodynamic instability
• Inhaled oxygen concentration (FiO2) \> 60%
• Untreated pneumothorax
• Patients who have undergone total pneumonectomy
• Hemoptysis
• Pulmonary bullae, etc.
• Patients with delirium and restlessness

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (2)

Respiratory rehabilitation center

Beijing, Beijing Municipality, 100144, China

RECRUITING

Shuo Chen

Beijing, China

COMPLETED

MeSH Terms

Conditions

Pulmonary Atelectasis

Interventions

Chest Wall Oscillation

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Respiratory Therapy; Therapeutics

Central Study Contacts

Shuo Chen

CONTACT

+86 13521362894; 983340122@qq.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physical therapy

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: March 5, 2026
• Study Start: March 15, 2026
• Primary Completion: April 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: March 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

CN (2)