Impact of Anterior Clinoid Process Pneumatization on Optic Canal and Retinal Nerve Fiber Layer

NCT07451080 | Completed

• 1 other identifier: EFSH-NIEC-2025-13-23
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve. Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.

Conditions

Anterior Clinoid Process Pneumatization; Optic Canal Morphometry; Retinal Nerve Fiber Layer Thickness

Keywords

Anterior Clinoid Process; Pneumatization; Optic Canal; Optic Canal Morphometry; Optical Coherence Tomography; Computed Tomography

Outcome Measures

Primary Outcomes (3)

• Optic Canal Length

  Optic canal length measured on computed tomography (CT) images.

  Baseline (retrospective review of CT images obtained between August 2018 and July 2025)

• Optic Canal Mean Diameter

  Optic canal mean diameter measured on computed tomography (CT) images.

  Baseline (retrospective review of CT images obtained between August 2018 and July 2025)

• Retinal Nerve Fiber Layer (RNFL) Thickness

  Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).

  Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)

Study Arms (2)

ACP Pneumatization Present

Participants with radiologically confirmed anterior clinoid process (ACP) pneumatization identified on computed tomography imaging.

ACP Pneumatization Absent

Participants without radiological evidence of anterior clinoid process (ACP) pneumatization on computed tomography imaging.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study population consists of adult patients aged 18 to 65 years who underwent both head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations at Elazığ Fethi Sekin City Hospital between August 2018 and July 2025. Patients will be retrospectively identified through the hospital electronic medical record and PACS archive systems. Participants will be categorized based on the presence or absence of anterior clinoid process (ACP) pneumatization on CT imaging.

You may qualify if:

• Adults aged 18 to 65 years.
• Availability of head and neck computed tomography (CT) imaging in the hospital archive.
• Availability of optical coherence tomography (OCT) examination records in the hospital archive.
• CT and OCT examinations performed between August 2018 and July 2025.

You may not qualify if:

• Age \<18 years or \>65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve).
• Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.

Sponsors & Collaborators

• Elazıg Fethi Sekin Sehir Hastanesi: lead

Study Sites (1)

Fethi Sekin City Hospital

Elâzığ, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: March 5, 2026
• Study Start: August 1, 2025
• Primary Completion: January 25, 2026
• Study Completion: February 1, 2026
• Last Updated: March 5, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)