From Presentation to Diagnosis: Patterns of Pleural Effusion

NCT07449624 | Completed

• 1 other identifier: R.26.02.3598
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Pleural effusion is a common clinical condition characterized by the accumulation of excess fluid within the pleural space due to disruption of normal pleural fluid dynamics. The etiology is diverse and includes systemic conditions such as congestive heart failure, liver cirrhosis, and renal disease, as well as localized pleural pathologies including infection, malignancy, and inflammatory disorders. Accurate classification of pleural effusion into transudative and exudative types, primarily using biochemical parameters such as Light's criteria, remains the cornerstone of diagnostic evaluation and guides subsequent clinical management.

Conditions

Pleural Mesothelioma

Keywords

Pleural effusion; Thoracoscopy; Pleural biopsy

Outcome Measures

Primary Outcomes (1)

• Distribution of underlying etiologies of pleural effusion among patients treated at Mansoura University Hospitals

  Number of patients diagnosed with each underlying cause of pleural effusion (e.g., malignancy, tuberculosis, parapneumonic effusion, heart failure, liver cirrhosis, renal failure, and others) based on clinical evaluation, radiological findings, and pleural fluid analysis.

  5 years

Study Arms (1)

Pleural effusion

evaluate the patterns, clinical features, pleural fluid characteristics, and etiologies of Pleural effusion among patients treated at Mansoura University, providing a comprehensive overview of the disease in this region.

Diagnostic Test: Pleural effusion pathology

Interventions

Pleural effusion pathology DIAGNOSTIC_TEST

describe the demographic and clinical characteristics of patients presenting with pleural effusion. To classify pleural effusions into transudates and exudates using Light's criteria. To determine the most common etiologies of pleural effusion in Mansoura University. To evaluate the relationship between clinical presentation, radiological findings,

Pleural effusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (\>18 years) diagnosed with pleural effusion between January 2020 and December 2025.

You may qualify if:

• All patients with documented pleural effusion confirmed by chest imaging (X-ray, ultrasound, or CT).
• Patients with complete clinical, laboratory, and radiological records.

You may not qualify if:

• Patients with incomplete medical records.
• Pediatric patients (\<18 years).
• Patients with post-surgical pleural collections unrelated to systemic or pathological causes.

Sponsors & Collaborators

• Mansoura University Hospital: lead

Study Sites (1)

Mohamed AbdElmoniem

Al Mansurah, 35516, Egypt

Location

MeSH Terms

Conditions

Mesothelioma, Malignant; Pleural Effusion

Condition Hierarchy (Ancestors)

Mesothelioma; Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Mesothelial; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Pleural Neoplasms; Lung Diseases; Respiratory Tract Diseases; Pleural Diseases

Study Officials

• Mohamed AbdElmoniem

  Lecturer of chest medicine faculty of medicine Mansoura university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer faculty of medicine

Study Record Dates

• First Submitted: February 26, 2026
• First Posted: March 4, 2026
• Study Start: January 1, 2020
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: March 4, 2026

Record last verified: 2026-03

Locations

EG (1)