Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy

NCT07446127 | Recruiting FDA Device

• 1 other identifier: 0011601-1
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is: To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone. This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups: Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups

Conditions

Periodontal Pockets; Periodontal Disease; Periodontal Attachment Loss

Keywords

diode laser; non surgical periodontal treatment

Outcome Measures

Primary Outcomes (1)

• PPD

  periodontal pocket depth

  prior to treatment and 12 weeks and 6 months after treatment

Secondary Outcomes (2)

• CAL

  prior to treatment and 12 weeks and 6 months after the treatment

• BOP

  prior to treatment and 12 weeks and 6 months after the treatment

Study Arms (2)

test quadrants

EXPERIMENTAL

two contralateral jaw quadrants in each patient mouth will undergo RsD and Laser Diode assisted SRP treatment

Device: LASER assisted SRP

control quadrants

ACTIVE COMPARATOR

two contralateral jaw quadrants in each patient mouth (same patient cohort) will undergo RsD treatment only

Device: RsD

Interventions

LASER assisted SRP DEVICE

Two quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only

test quadrants

RsD DEVICE

mechanical root surface debridement with periodontal curettes

control quadrants

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Systemically healthy patients
• Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant
• Each patient presented ≥ 30% of sites involved
• At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.

You may not qualify if:

• History of systemic diseases affecting the periodontium
• Smokers and alcoholic patients
• Use of medication within the last 6 months, which might affect the periodontal status
• Pregnant and lactating women
• Patients who had any periodontal treatment ≤ 12 months before the examination.

Sponsors & Collaborators

• Tel Aviv University: lead

Study Sites (1)

Dr Younis Mahmoud

Afula, North, 1839203, Israel

RECRUITING

Related Publications (14)

• Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol. 2008 Sep;35(8 Suppl):29-44. doi: 10.1111/j.1600-051X.2008.01259.x.

  PMID: 18724840 BACKGROUND

• Jia L, Jia J, Xie M, Zhang X, Li T, Shi L, Shi H, Zhang X. Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis: a network meta-analysis of randomized controlled clinical trials. Lasers Med Sci. 2020 Mar;35(2):473-485. doi: 10.1007/s10103-019-02875-5. Epub 2019 Nov 5.

  PMID: 31691054 BACKGROUND

• Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, Sperr W. Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg. 1997 Feb;15(1):33-7. doi: 10.1089/clm.1997.15.33.

  PMID: 9467340 BACKGROUND

• Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000. 2004;36:59-97. doi: 10.1111/j.1600-0757.2004.03679.x. No abstract available.

  PMID: 15330944 BACKGROUND

• Gojkov-Vukelic M, Hadzic S, Dedic A, Konjhodzic R, Beslagic E. Application of a diode laser in the reduction of targeted periodontal pathogens. Acta Inform Med. 2013 Dec;21(4):237-40. doi: 10.5455/aim.2013.21.237-240. Epub 2013 Dec 4.

  PMID: 24554796 BACKGROUND

• Matarese G, Ramaglia L, Cicciu M, Cordasco G, Isola G. The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. Photomed Laser Surg. 2017 Dec;35(12):702-709. doi: 10.1089/pho.2017.4288. Epub 2017 Sep 14.

  PMID: 28945145 BACKGROUND

• Dukic W, Bago I, Aurer A, Roguljic M. Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study. J Periodontol. 2013 Aug;84(8):1111-7. doi: 10.1902/jop.2012.110708. Epub 2012 Oct 17.

  PMID: 23075433 BACKGROUND

• De Micheli G, de Andrade AK, Alves VT, Seto M, Pannuti CM, Cai S. Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial. Lasers Med Sci. 2011 Jan;26(1):43-8. doi: 10.1007/s10103-009-0753-5. Epub 2010 Feb 4.

  PMID: 20131073 BACKGROUND

• Pawelczyk-Madalinska M, Benedicenti S, Salagean T, Bordea IR, Hanna R. Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials. J Inflamm Res. 2021 Jun 15;14:2515-2545. doi: 10.2147/JIR.S304946. eCollection 2021.

  PMID: 34163210 BACKGROUND

• Jia L, Jia J, Wu M, Li T, Zhao C, Shi H, Zhang X. Probing depth reduction of laser application in periodontal therapy: a network meta-analysis. Lasers Med Sci. 2022 Mar;37(2):1217-1226. doi: 10.1007/s10103-021-03376-0. Epub 2021 Jul 29.

  PMID: 34327566 BACKGROUND

• Gur AT, Guncu GN, Akman AC, Pinar A, Karabulut E, Nohutcu RM. Evaluation of GCF IL-17, IL-10, TWEAK, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis. J Periodontol. 2022 Aug;93(8):1161-1172. doi: 10.1002/JPER.21-0494. Epub 2022 Jan 25.

  PMID: 34962665 BACKGROUND

• Mokhtari MR, Ahrari F, Dokouhaki S, Fallahrastegar A, Ghasemzadeh A. Effectiveness of an 810-nm Diode Laser in Addition to Non-surgical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Single-Blind Clinical Trial. J Lasers Med Sci. 2021 Jul 19;12:e37. doi: 10.34172/jlms.2021.37. eCollection 2021.

  PMID: 34733760 BACKGROUND

• Lu JW, Huang SH, Lei XX, Deng L, Luo LJ. Clinical outcomes of diode laser as an adjunct to nonsurgical periodontal therapy for residual periodontal pockets in mandibular second molars-a randomized controlled clinical trial. Clin Oral Investig. 2023 Aug;27(8):4493-4501. doi: 10.1007/s00784-023-05071-6. Epub 2023 May 23.

  PMID: 37219608 BACKGROUND

• Alizadeh Tabari Z, Pournasir L, Mohammadreza S, Anbari F. Clinical Efficacy of the 940-nm Diode Laser in the Treatment of Recurrent Pockets in the Periodontal Maintenance Phase. J Lasers Med Sci. 2021 Nov 6;12:e68. doi: 10.34172/jlms.2021.68. eCollection 2021.

  PMID: 35155153 BACKGROUND

MeSH Terms

Conditions

Periodontal Diseases; Periodontal Pocket; Periodontal Attachment Loss

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Periodontitis; Periodontal Atrophy

Central Study Contacts

Mahmoud Dr Younis, DMD

CONTACT

+972544934823; younisma@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Model Details: split mouth

Study Record Dates

• First Submitted: February 18, 2026
• First Posted: March 3, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 3, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)