Comparison of Rate and Amount of Orthodontic Space Closure

NCT07445321 | Completed

• 1 other identifier: BAnis
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is to calculate rate and amount of space closure between fresh vs healed as well as maxilla and mandible.

Conditions

Orthodontic Extraction

Keywords

Fixed Orthodontic Treatment; Fresh extraction socket; Healed extraction socket; premolar

Outcome Measures

Primary Outcomes (1)

• To compare rate of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.

  This study will be useful in making the timely decision for extraction of premolars and estimation of orthodontic treatment duration as well.

  four time points are taken. T0: Baseline, T1: One month, T2: Two months, T3: Three months

Secondary Outcomes (1)

• To compare amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.

  Space closure at T3 is subtracted from T0

Study Arms (1)

fresh vs healed extraction socket

EXPERIMENTAL

Comparison of rate and amount of space closure in fresh vs healed extraction socket

Procedure: Space Closure

Interventions

Space Closure PROCEDURE

Space Closure in fresh vs healed extraction socket

Also known as: Extraction

fresh vs healed extraction socket

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-35 years.
• Patients undergoing fixed appliance treatment.
• Good oral hygiene and periodontal support.
• Patients with all first premolar's extraction treatment plan.
• Atraumatic extraction.

You may not qualify if:

• History of previous orthodontic treatment
• Systemic diseases like diabetes, hypertension etc
• Any bone pathology or taking medicines like bisphosphonates
• Patients with clefts or any syndromic condition.
• Patients with old extraction socket.

Sponsors & Collaborators

• Dow University of Health Sciences: lead

Study Sites (1)

Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

Karachi, Sindh, 75300, Pakistan

Location

MeSH Terms

Conditions

Bicuspid Aortic Valve Disease

Interventions

Orthodontic Space Closure

Condition Hierarchy (Ancestors)

Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Aortic Valve Disease; Heart Valve Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Orthodontics, Corrective; Orthodontics; Dentistry

Study Officials

• Sadia Rizwan, BDS, FCPS, CHPE

  Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Each patients mouth is splitted into four quadrants.Intervention is done either on left or right side randomly allocated

Study Record Dates

• First Submitted: January 29, 2026
• First Posted: March 3, 2026
• Study Start: February 15, 2023
• Primary Completion: December 20, 2023
• Study Completion: February 9, 2024
• Last Updated: March 3, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)