Impact of Time-restricted Eating on Sleep, Glucose and Insulin Sensitivity

NCT07444671 | Completed

• 1 other identifier: Protocol # 18-8249H
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to see how the timing of eating impacts participants sleep and how the body responds to sugar.

Conditions

Time Restricted Eating

Outcome Measures

Primary Outcomes (2)

• 24 hour Continuous Glucose Monitoring (Average glucose)

  Participants will wear a continuous glucose monitor for 2 weeks. Week 1 will be compared to week 2.

  2 weeks

• Oral glucose tolerance test (2 hour glucose)

  Participants will complete an oral glucose tolerance test on 2 occasions (end of week 1 and end of week 2)

  2 weeks

Study Arms (2)

Control

ACTIVE COMPARATOR

For the week between equipment pickup and the first overnight stay participants will maintain normal eating habits and eat across the day based on timing discussed with study staff. During this time study staff will ask participants to record meals by taking pictures and texting them to the Lab.

Other: Control eating

Time restricted eating

EXPERIMENTAL

For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day. During this time study staff will ask participants to record your meals by taking pictures and texting them to the Lab.

Other: Time restricted eating

Interventions

Time restricted eating OTHER

For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day.

Time restricted eating

Control eating OTHER

Participants consume a normal eating schedule across the day.

Control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adult men and women ages 18-65
• habitual sleep duration between 7-9.25 hours
• lived at altitude for at least 3 months.

You may not qualify if:

• Diagnosed acute or chronic physical or psychiatric disorders;
• diagnosed sleep disorders;
• not participating in another research study concurrently which could increase risks, such as those involving medication or blood sampling;
• shiftwork in the 6 months before the study; travel more then one time zone three weeks prior to the study;
• blood donation 30 days prior to the first study visit;
• illicit drug use, prescribed medication use (excluding over the counter products) 30 days prior to the study visit;
• everyday nicotine use;
• regular consumption of over 400mg caffeine per day in the past month; and consumption of over 14 alcoholic beverages a week, or more than 4 alcoholic beverages in a single day over the past month for men and consumption of over 7 alcoholic beverages a week, or more than 3 alcoholic beverages in a single day over the past month for women.

Sponsors & Collaborators

• Colorado State University: lead

Study Sites (1)

Sleep and Metabolism Laboratory

Fort Collins, Colorado, 80523, United States

Location

MeSH Terms

Conditions

Intermittent Fasting

Condition Hierarchy (Ancestors)

Fasting; Feeding Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2026
• First Posted: March 3, 2026
• Study Start: December 7, 2018
• Primary Completion: May 25, 2021
• Study Completion: May 25, 2021
• Last Updated: March 4, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)