Home-Based Physiotherapy in Oncology

NCT07440433 | Not Yet Recruiting

• 1 other identifier: PRADA-HUG
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients. The programme combines aerobic cycling exercise, resistance training, and mental preparation strategies, delivered at home with regular professional supervision. The main questions this study aims to answer are: Is a 6-month supervised home-based physiotherapy programme feasible in terms of recruitment, adherence, and retention? Is the programme safe for oncology patients undergoing or having recently completed cancer treatment? Is the programme acceptable and satisfactory from the patient's perspective? How do physical function and health-related quality of life change over the course of the programme? This is a single-arm feasibility study with no comparison group. Participants will: Receive a stationary exercise bike delivered and installed at their home Follow a 6-month individualized physiotherapy programme including: Three weekly sessions combining moderate-intensity cycling and resistance exercises Wear a connected activity watch during exercise sessions to monitor heart rate and exercise duration Receive weekly supervision from oncology-trained physiotherapists through alternating in-person hospital visits and structured phone calls Complete physical function assessments and questionnaires on quality of life, fatigue, and programme satisfaction at baseline, mid-program, and study completion The results of this study will inform the design of a future larger controlled trial and contribute to the development of accessible home-based rehabilitation programmes for oncology patients.

Conditions

Rehabilitation Exercise; Oncologic Diseases

Outcome Measures

Primary Outcomes (4)

• Retention rate

  Percentage of participants completing the 6-month intervention and final assessments.

  6 months

• Adherence to prescribed exercise sessions

  Percentage of planned home-based exercise sessions completed over 6 months.

  6 months

• Equipment installation and usability

  Percentage of participants with successful delivery, installation, and safe use of the home-based exercise equipment.

  6 months

• Safety of the intervention

  Number and type of adverse events and serious adverse events related to the programme.

  6 months

Secondary Outcomes (6)

• 6-minute walk test

  Baseline and 6 months

• Peak oxygen uptake (VO₂peak)

  Baseline and 6 months

• 5 Times Sit-to-Stand Test (5xSST)

  Baseline and 6 months

• Handgrip strength

  Baseline and 6 months

• Health-related quality of life (EORTC QLQ-C30 global health status score)

  Baseline, 3 months, and 6 months

Study Arms (1)

Home-based supervised physiotherapy programme

OTHER

Participants enrolled in this single-arm study receive a 6-month supervised home-based physiotherapy programme combining aerobic cycling, resistance training, and mental preparation, delivered and monitored by oncology-trained physiotherapists.

Behavioral: Home-based cycling + resistance training with physiotherapist supervision

Interventions

Home-based cycling + resistance training with physiotherapist supervision BEHAVIORAL

Participants complete a 6-month supervised home-based physiotherapy programme. The intervention includes three weekly exercise sessions consisting of approximately 20 minutes of moderate-intensity aerobic cycling followed by 20 minutes of resistance training. Exercise intensity is prescribed and monitored using perceived exertion and heart rate. A stationary exercise bike is delivered and installed at the participant's home. Participants receive weekly supervision by oncology-trained physiotherapists through alternating in-person hospital visits and structured telephone calls. Mental preparation strategies, including motivational support and goal setting, are integrated during in-person visits to support adherence and self-management.

Home-based supervised physiotherapy programme

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years
• Diagnosis of solid cancer, undergoing or recently completed treatment.
• Overall survival greater than 12 months, as judged by the treating oncologist
• Clinically stable and deemed fit for moderate exercise by the treating oncologist
• Able to use an exercise bike
• Home environment suitable for delivery and installation of the exercise bike
• Able to understand the study language and follow study instructions
• Able to give a written informed consent

You may not qualify if:

• Medical contraindication to moderate exercise (e.g. uncontrolled cardiac or pulmonary disease, recent myocardial infarction, severe anemia or acute infection, unstable bone metastases or high fracture risk)
• Cognitive impairment preventing active participation
• Physical inability to perform the prescribed exercise programme, including cycling and resistance exercises.
• Participation in another intensive rehabilitation program
• Any other condition that, in the opinion of the treating oncologist or investigator, makes participation unsafe or not feasible
• Pregnant or lactating women.

Sponsors & Collaborators

• University Hospital, Geneva: lead

Study Sites (1)

HUG

Geneva, 1205, Switzerland

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Floryane Dr Kim

CONTACT

+41 22 372 98 62; floryane.kim@hug.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 12, 2026
• First Posted: February 27, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)