Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study

NCT07438769 | Not Yet Recruiting

• 2 other identifiers: 23V0123022026USRA
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue. This prospective cohort study aims to determine whether early ultrasound features of scars and nerves predict persistent clinically significant scar pain at 3 and 6 months. Ultrasound measures include scar thickness, echogenicity, Power Doppler vascularity, dynamic adhesion (gliding) assessment, and ultrasound signs of nerve involvement ("US-nerve positive"). Clinical outcomes include pain intensity (NRS), neuropathic pain screening (DN4), and functional interference.

Conditions

Burn Scar Pain; Neuropathic Pain; Combat-Related Burn Injury; Scar-Related Pain

Keywords

Burn scar pain; ultrasound; nerve entrapment; blast injury; drone injury; neuropathic pain; chronic pain prediction

Outcome Measures

Primary Outcomes (1)

• Persistent clinically significant scar pain

  Persistent scar pain defined as Numeric Rating Scale (NRS) ≥4 during movement or on light touch at follow-up assessment. The primary endpoint is the presence of clinically significant pain at 3 months after enrollment.

  3 mounth

Secondary Outcomes (1)

• Persistent Clinically Significant Scar Pain at 6 Months

  6 mounth

Study Arms (2)

Persistent Scar Pain

articipants who develop clinically significant persistent scar pain defined as NRS ≥4 during movement or light touch at 3 or 6 months follow-up after burn injury.

No Persistent Scar Pain

Participants without clinically significant persistent scar pain (NRS \<4 during movement and light touch) at 3 and 6 months follow-up.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult patients (≥18 years) with clinically formed burn scars following blast-related, drone-related, or comparable burn injuries. Participants will be enrolled between 2 and 12 weeks after injury and followed prospectively for 6 months. Scars may be located on extremities, chest wall, or neck. The study population represents individuals at risk of developing persistent scar pain after combat-related or high-energy burn trauma.

You may qualify if:

• Age ≥18 years
• Burn injury with clinically formed scar
• Enrollment 2-12 weeks after injury
• Scar located on extremities, chest wall, or neck
• Ability to provide written informed consent

You may not qualify if:

• Severe cognitive impairment preventing valid questionnaires
• Hemodynamic instability or inability to complete baseline evaluation
• Active systemic infection (enrollment deferred until stable)
• Pre-existing chronic pain condition unrelated to burn scar that would confound outcomes (investigator judgment)

Sponsors & Collaborators

• Ukrainian Society of Regional Anesthesia and Pain Therapy: lead

Study Sites (1)

Vinnitsya Regional Clinical Hospital n.a Pirogov

Vinnitsya, Select, 21018, Ukraine

Location

Related Links

• Related Info

MeSH Terms

Conditions

Neuralgia; Nerve Compression Syndromes; Blast Injuries

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Barotrauma; Wounds and Injuries

Central Study Contacts

Dmytro Dmytriiev, PhD.Professor

CONTACT

+380674309449; mddmytriiev@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: February 22, 2026
• First Posted: February 27, 2026
• Study Start: March 24, 2026
• Primary Completion: May 23, 2026
• Study Completion: May 23, 2026
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

UA (1)