NCT07438561

Brief Summary

The study was conducted to compare the effects of hold-relax and muscle energy technique on pain, range of motion an lower extremity function in patients with post-traumatic knee stiffness.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
68

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2025

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

February 23, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 27, 2026

Completed
Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

10 months

First QC Date

February 23, 2026

Last Update Submit

February 23, 2026

Conditions

Keywords

Knee StiffnessRange of motionexerciseexercise therapymuscle energy technique

Outcome Measures

Primary Outcomes (3)

  • Numeric Pain Rating Scale (NPRS)

    Numeric Pain Rating Scale is a subjective measure using which patient's rate their pain. It consists of 11 points, having an overall score ranging from 0 to 10, where: 0, 1 - 3, 4 - 6, 7 - 10 represents no pain, mild, moderate and the most severe pain respectively

    From enrollment to the end of the treatment at 8 weeks.

  • Universal Goniometer

    Range of motion of joints are usually assessed by a device known as universal goniometer. meter has two arms stationary as well as movable arm. The Centre of the goniometer is known as fulcrum. Through goniometer in each plane joint ranges are measured.

    From enrollment to the end of the treatment at 8 weeks.

  • Lower Extremity Function Scale (LEFS)

    The Lower Extremity Functional Scale (LEFS) is a 20-item self-report questionnaire assessing functionality in patients with knee and other lower limb disorders. Patients rate their difficulty with activities on a 0-4 scale (0=extreme difficulty/unable, 4=no difficulty), with a total score out of 80; higher scores indicate better function.

    From enrollment to the end of the treatment at 8 weeks.

Study Arms (2)

Hold-Relax Technique

EXPERIMENTAL
Other: Hold-Relax TechniqueOther: Standard Physical Therapy

Muscle Energy Technique

ACTIVE COMPARATOR
Other: Muscle Energy TechniqueOther: Standard Physical Therapy

Interventions

Hold-Relax: Patient was in prone position, therapist was on the affected site, the affected knee was bent to the available and pain free range at that range therapist applied pressure and held it for 8-10 seconds repeated for 10 times. 3 sessions per week for a total of 8 weeks.

Hold-Relax Technique

Muscle Energy Technique: Patient was in prone position, therapist was on the affected site, the affected knee was bent to the available and pain free range at that range therapist applied pressure and asked the patient to move his knee in extension against the resistance applied by therapist for 10 seconds. And then patient flexed his knee actively and process was repeated for 10 times. 3 sessions per week for a total of 8 weeks.

Muscle Energy Technique

* Hot packs were applied to patients for a period of 10 minutes. * Mulligan mobilization techniques were performed on the knee joint. * Knee isometrics were done.

Hold-Relax TechniqueMuscle Energy Technique

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients who had fracture and treated either with POP or ORIF.
  • Fracture healing completed.
  • Both genders of age between 18-35.
  • Conservative treatment of fracture with POP for minimum 6 weeks.
  • NPRS more than or equal to 2.

You may not qualify if:

  • Pathological fracture.
  • Post-traumatic myositis ossificans.
  • Ligamental or Meniscal tears.
  • Any tumor in the knee region.
  • Osteoarthritis.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Naseer Hospital

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (7)

  • Moradi MR. The effect of a muscle energy session on increasing knee extension in People with shortness of knee posterior muscles. National University. 2020

    BACKGROUND
  • Xu L, Li J, Sheng Q, Wang G. Clinical Application of Muscle Energy Technique for Knee Function Recovery After Total Knee Arthroplasty. J Pain Res. 2025 Oct 14;18:5409-5416. doi: 10.2147/JPR.S537482. eCollection 2025.

    PMID: 41114387BACKGROUND
  • Valenza MC, Torres-Sanchez I, Cabrera-Martos I, Valenza-Demet G, Cano-Cappellacci M. Acute Effects of Contract-Relax Stretching vs. TENS in Young Subjects With Anterior Knee Pain: A Randomized Controlled Trial. J Strength Cond Res. 2016 Aug;30(8):2271-8. doi: 10.1097/JSC.0000000000000215.

    PMID: 27457916BACKGROUND
  • Nazary-Moghadam S, Yahya-Zadeh A, Zare MA, Ali Mohammadi M, Marouzi P, Zeinalzadeh A. Comparison of utilizing modified hold-relax, muscle energy technique, and instrument-assisted soft tissue mobilization on hamstring muscle length in healthy athletes: Randomized controlled trial. J Bodyw Mov Ther. 2023 Jul;35:151-157. doi: 10.1016/j.jbmt.2023.04.079. Epub 2023 Apr 21.

    PMID: 37330762BACKGROUND
  • Bhosale P, Kolke Pt S. Effectiveness of instrument assisted soft tissue mobilization (IASTM) and muscle energy technique (MET) on post-operative elbow stiffness: a randomized clinical trial. J Man Manip Ther. 2023 Oct;31(5):340-348. doi: 10.1080/10669817.2022.2122372. Epub 2022 Sep 28.

    PMID: 36171728BACKGROUND
  • Balasundaram AP, Sreerama Rajan S. Short-term effects of mobilisation with movement in patients with post-traumatic stiffness of the knee joint. J Bodyw Mov Ther. 2018 Apr;22(2):498-501. doi: 10.1016/j.jbmt.2017.06.007. Epub 2017 Jun 15.

    PMID: 29861257BACKGROUND
  • Khan T, Rizvi MR, Sharma A, Ahmad F, Hasan S, Uddin S, Sidiq M, Ammari A, Iqbal A, Alghadir AH. Assessing muscle energy technique and foam roller self-myofascial release for low back pain management in two-wheeler riders. Sci Rep. 2024 May 27;14(1):12144. doi: 10.1038/s41598-024-62881-8.

    PMID: 38802553BACKGROUND

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Ali Raza, MS-OMPT

    Riphah International University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 23, 2026

First Posted

February 27, 2026

Study Start

January 1, 2025

Primary Completion

October 31, 2025

Study Completion

October 31, 2025

Last Updated

February 27, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations