NCT07437885

Brief Summary

The study aimed to evaluate the effect of Hyaluronic Acid-based gel use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient satisfaction, analyzed at baseline and 6 months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at P25-P50 for phase_1

Timeline
Completed

Started Sep 2024

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2024

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2025

Completed
11 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 10, 2025

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

February 20, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 27, 2026

Completed
Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

11 months

First QC Date

February 20, 2026

Last Update Submit

February 26, 2026

Conditions

Gingival Recession

Outcome Measures

Primary Outcomes (2)

  • Complete root coverage

    for evaluating rate of complete root coverage

    6 months postsurgery

  • Mean root coverage

    for evaluating rate of mean root coverage

    6 months postsurgery

Secondary Outcomes (24)

  • Plaque Index

    Baseline

  • Plaque Index

    6 months post surgery

  • Gingival Index

    Baseline

  • Gingival index

    6 montsh post surgery

  • Probing pocket depth

    Baseline

  • +19 more secondary outcomes

Study Arms (2)

Coranally Advanced Flap and Hyaluronic Acid-Based Gel application

ACTIVE COMPARATOR

Coronally advanced flap and adjunctive use of 0.8% hyaluronic acid-based gel

Drug: Hyaluronic acid

Coranally Advanced Flap

PLACEBO COMPARATOR

Only Coronally advanced flap

Other: Steril saline solution

Interventions

Hyaluronic acidDRUG

0.8% hyaluronic acid gel (Gengigel Oral Forte Gel, Ricefarma, Milan, Italy)

Coranally Advanced Flap and Hyaluronic Acid-Based Gel application
Steril saline solutionOTHER

Mix 8 teaspoons of salt into 4 L of distilled water

Coranally Advanced Flap

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Double-sided type 1 gingival recession
  • No inflammation

You may not qualify if:

  • active periodontal disease
  • smokers
  • pregnant and breastfeeding women
  • individuals with unilateral GR

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Figen Öngöz Dede

Ordu, 52100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Gingival Recession

Interventions

Hyaluronic Acid

Condition Hierarchy (Ancestors)

Gingival DiseasesPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesPeriodontal Atrophy

Intervention Hierarchy (Ancestors)

GlycosaminoglycansPolysaccharidesCarbohydrates

Study Officials

  • Figen Öngöz Dede, Prof

    Ordu Universitesi

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical professor

Study Record Dates

First Submitted

February 20, 2026

First Posted

February 27, 2026

Study Start

September 1, 2024

Primary Completion

July 30, 2025

Study Completion

August 10, 2025

Last Updated

February 27, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)