Food-related Quality of Life in Patients With Cancer

NCT07437326 | Not Yet Recruiting

• 2 other identifiers: 69HCL25_09082025-A02292-47
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 3

Brief Summary

Food plays a fundamental role in quality of life. In patients with cancer psychological burden and treatment-related side effects can impact appetite, taste perception and pleasure of eating, making nutritional management more challenging. Given the central role of food and nutrition in maintaining physical health and psychological well-being, it is essential to better understand the factors that contribute to food-related quality of life in order to improve the quality of life of patients with cancer. Despite the importance of these psychological aspects, current assessments tools do not adequately measure the impact of cancer on the food-related quality of life. In a study entitled "CANUT-QVA" a specific questionnaire measuring nine dimensions of food related quality of life was developed, allowing for a better understanding of how patients perceive and experience their diet. This instrument consists of 46 items and explores nine dimensions, its use showing a significant decrease in food related quality of life of patients with breast cancer, opening the way for targeted interventions to improve nutritional well being and overall quality of life in cancer patients. The present study aims to analyse various factors - such as oral health, sensory profile and clinical characteristics - associated with food-related quality of life in patients with cancer (gastrointestinal, head and neck, lung, breast and gynecologic cancer) during or after treatment, in order to develop a predictive model of food related quality of life. The main objective of this project is to identify the population at highest risk, so as to better tailor nutritional interventions for patients with cancer, considering both the type of treatment received and the phase, during or after treatment. The food-related quality of life questionnaire containing 46 items will be used to measure the primary outcome.

Conditions

Breast Cancer; Head and Neck Cancers; Gynecologic Cancer; Gastrointestinal Cancer; Lung Cancer

Keywords

cancer; food; nutrition; perceptions; quality of life related to food

Outcome Measures

Primary Outcomes (1)

• The food-related quality of life in patients with cancer (gastrointestinal, breast, head and neck, gynecologic, lung).

  The food-related quality of life questionnaire containing 46 items will be used to measure the outcome. The questionnaire uses a Likert scale: 1 = never; 2 = sometimes; 3 = often; 4 = always.

  day of inclusion

Study Arms (2)

Patients under treatment

Patients with cancer (gastrointestinal, breast, head and neck, gynecologic, lung), under treatment from at least two months, receiving active anticancer treatment (chemotherapy, targeted therapy, immunotherapy, etc., except patients undergoing head and neck radiotherapy) in a standard of care program.

Other: Self-reported questionnaires; Other: Salivary and sensory tests

Patients after treatment

Patients who have undergone anticancer treatment (chemotherapy, targeted therapy, immunotherapy, etc.) having completed it at least 3 months and no more then 12 months before inclusion.

Other: Self-reported questionnaires; Other: Salivary and sensory tests

Interventions

Self-reported questionnaires OTHER

Self-reported questionnaires will be used to asses patient's food-related quality of life (QVA questionnaire), global quality of life (EORTC QLQ-C30 questionnaire), evaluation of oral symptoms and perceptions.

Patients after treatment; Patients under treatment

Salivary and sensory tests OTHER

Objective tests will be performed to measure the salivary quality and quantity and taste and smell perceptions.

Patients after treatment; Patients under treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with different types of cancer gastrointestinal, breast, gynecologic, head and neck, lung, aged between 18 years or older. Two cohorts are considered: patients under treatment (chemotherapy, targeted therapy, immunotherapy, etc., except patients undergoing head and neck radiotherapy) from at least two months and patients having undergone anticancer treatment having completed it at least 3 months and no more than 12 months before inclusion. The necessary number of patients is 180, 90 patients in each cohort.

You may qualify if:

• Patient aged 18 years or older;
• Patient with gastrointestinal, breast, gynecologic, head and neck, lung
• Patient receiving a cancer treatment (chemotherapy, targeted therapy, immunotherapy, etc.) from at least two months;
• Patient capable of filling a questionnaire;
• Patient having given his free, informed and express consent.

You may not qualify if:

• \- Patient having a radiotherapy treatment for a head or neck cancer;
• Patient having presented nausea and vomiting during the last 24 hours;
• Patient with severe inflammation of the mouth or throat (ulcers, mucus);
• Patient with cognitive disorders and memory loss;
• Pregnant women or breastfeeding;
• Adult under legal protection (guardianship, curatorship).

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (3)

Hôpital Femme Mère Enfant

Bron, France

Location

Hôpital de la Croix Rousse

Lyon, France

Location

Hôpital Lyon Sud

Oullins, France

Location

MeSH Terms

Conditions

Breast Neoplasms; Head and Neck Neoplasms; Gastrointestinal Neoplasms; Lung Neoplasms; Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Amandine BRUYAS, Dr

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amandine BRUYAS, Dr

CONTACT

478861628; amandine.bruyas@chu-lyon.fr

Irina Elena ANTOCHI

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: February 27, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (3)