Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors
A Community-Engaged Approach to Culturally Adapting an Intervention to Increase Uptake of Genetic Testing Among African American Cancer Survivors
2 other identifiers
interventional
85
1 country
1
Brief Summary
The goal of this clinical trial is to culturally adapt an educational genetic counseling intervention to increase the uptake in genetic counseling and testing among African Americans at risk for heredity cancers. With the help of community stakeholders and clinical genetic professionals the investigators will:
- adapt and refine a culturally relevant online educational genetic counseling program for at-risk African Americans
- Test the effects of the educational program
- collaborate with community leaders and clinical genetic professionals to translate study findings, develop a road map for dissemination to the community, and identify barriers to prepare for future trials. Participants from Detroit Research on Cancer Survivor group will be offered enrollment. Once consent is obtained, questionnaires will be completed before an online genetic counselling intervention immediately after, and at 3 months
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Apr 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 11, 2026
CompletedFirst Posted
Study publicly available on registry
February 27, 2026
CompletedStudy Start
First participant enrolled
April 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2029
February 27, 2026
February 1, 2026
3.3 years
February 11, 2026
February 21, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Uptake of genetic counseling and genetic testing
One item question will ask whether participants have participated in genetic counseling and genetic testing (Yes or No)
3 month follow Up
Secondary Outcomes (15)
Intention to undergo genetic counseling and testing
1 day Pre Intervention to 1 day Post Intervention
Sharing Your Results
3 month follow up
Major Experiences of Discrimination
1 day prior to intervention
Everyday Experiences of Discrimination
1 day prior to intervention
Interpersonal Processes of Care Survey
1 day prior to intervention
- +10 more secondary outcomes
Other Outcomes (11)
Age at enrollment (measured in years)
1 day prior to intervention
PROMIS (Patient-Reported Outcomes Measurement Information System) Anxiety Scale
1 day prior to intervention
PROMIS (Patient-Reported Outcomes Measurement Information System) Depression Scale
1 day prior to intervention
- +8 more other outcomes
Study Arms (1)
Online Culturally adapted Genetic Counseling Information
EXPERIMENTALCulturally developed online Genetic counseling information will be provided. Questionnaires will be administered pre and post genetic counseling intervention as well as 3 months post intervention
Interventions
Testing the effects of the educational intervention designed to increase the uptake of genetic counseling testing among at-risk African American survivors
Eligibility Criteria
You may qualify if:
- Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS)
- Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013
- have received or currently receiving care at Karmanos Cancer Institute
- meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below
- Female breast
- personal diagnosis at age ≤50
- personal history of the triple-negative subtype
- at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age \<50
- at least 1 close relative diagnosed with ovarian cancer
- + close relatives diagnosed with breast or prostate cancer
- age \<50 AND another primary breast cancer at any age
- + primary breast cancers at any age
- OR Prostate
- personal history of high-risk or very high-risk prostate cancer
- personal history of regional or metastatic prostate cancer
- +6 more criteria
You may not qualify if:
- Previous genetic counseling and/or testing
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Felicity WK Harper, Ph.D
Barbara Ann Karmanos Cancer Institute
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
February 11, 2026
First Posted
February 27, 2026
Study Start
April 1, 2026
Primary Completion (Estimated)
July 1, 2029
Study Completion (Estimated)
July 1, 2029
Last Updated
February 27, 2026
Record last verified: 2026-02