Comparative Outcomes of Radiofrequency Ablation of Concealed and Manifest Accessory Pathways: a Single Center, Retrospective Observational Study

NCT07435181 | Not Yet Recruiting

• 1 other identifier: AP-STUDY
• Study Type: observational
• Target: 220
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this observational, retrospective study is to evaluate, comparatively, procedural outcomes of APs (Accessory pathway) ablation according to the conduction properties (i.e., manifest vs. concealed) and to assess both short- and long-term outcomes of RFA (RF ablation).

Conditions

Atrioventricular Reentrant Tachycardias; Wolff-Parkinson-White (WPW) Syndrome

Keywords

Accessory pathway; Radiofrequency ablation; Wolff-Parkinson-White

Outcome Measures

Primary Outcomes (1)

• Acute procedural success

  At the end of the index procedure

Secondary Outcomes (2)

• Procedural complexity

  From the end of the index procedure to discharge and at the ambulatory follow-up visits

• Durability of successful radiofrequency ablation

  From the end of the index procedure to discharge and at the ambulatory follow-up visits

Eligibility Criteria

• Age: 5 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients who consecutively underwent an electrophysiological (EP) study at San Raffaele Scientific Institute for EP study due to paroxysmal SVT with documented acessory pathway

You may qualify if:

• Patients who consecutively underwent an electrophysiological (EP) study between 2005 and 2023 at San Raffaele Scientific Institute are included if they met one of the following criteria:
• Patients referred for EP study due to:
• EITHER clinical suspicion of paroxysmal supraventricular tachycardia without prior documentation of ventricular pre-excitation and/or supraventricular arrhythmia (SVA) on 12-lead surface electrocardiogram, OR with electrocardiographic evidence of SVA, AND electrophysiological confirmation of atrioventricular re-entrant tachycardia (AVRT) as the arrhythmic mechanism.
• Ventricular pre-excitation documented on serial 12-lead surface ECGs, with or without clinical episodes suggestive of AVRT, who underwent catheter ablation of the accessory pathway based on:
• The presence of high-risk electrophysiological features (e.g., short antegrade effective refractory period of the AP, rapid conduction during atrial fibrillation), or Induction of sustained AVRT during the EP study.
• Aged between 5 to 60 years old

You may not qualify if:

• Lack of pre-specified follow-up: only patients with at least 1 years follow-up ambulatory visit will be included in the study
• REDO CA procedure

Sponsors & Collaborators

• IRCCS Ospedale San Raffaele: lead

Related Publications (3)

• Santinelli V, Radinovic A, Manguso F, et al. The natural history of asymptomatic ventricular pre-excitation a long-term prospective follow-up study of 184 asymptomatic children. J Am Coll Cardiol. 2009;53(3):275-280. doi:10.1016/j.jacc.2008.09.037

  BACKGROUND

• Pappone C, Santinelli V, Rosanio S, et al. Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study. J Am Coll Cardiol. 2003;41(2):239-244. doi:10.1016/s0735- 1097(02)02706-7

  BACKGROUND

• Jackman WM, Wang XZ, Friday KJ, et al. Catheter ablation of accessory atrioventricular pathways (Wolff- Parkinson-White syndrome) by radiofrequency current. N Engl J Med. 1991;324(23):1605-1611. doi:10.1056/NEJM199106063242301

  BACKGROUND

MeSH Terms

Conditions

Tachycardia, Atrioventricular Nodal Reentry; Wolff-Parkinson-White Syndrome; Syndrome; Pre-Excitation Syndromes

Condition Hierarchy (Ancestors)

Tachycardia, Reciprocating; Tachycardia; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Defects, Congenital; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Disease

Central Study Contacts

Simone Gulletta, MD

CONTACT

02 2643 7484; gulletta.simone@hsr.it

Marcello Cosenza, MD

CONTACT

02 2643 689; cosenza.marcello@hsr.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: February 27, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share