Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis

NCT07433894 | Not Yet Recruiting DMC

• 1 other identifier: Jia-scoliosis
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life. This cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population.

Conditions

Scoliosis

Keywords

Juvenile Idiopathic Arthritis; Scoliosis; Functional Outcomes; Postural Alignment; Pediatric Rheumatology

Outcome Measures

Primary Outcomes (1)

• Prevalence of Scoliosis in Children With Juvenile Idiopathic Arthritis

  Proportion of participants with scoliosis, defined as a Cobb angle ≥10° measured on standing spinal radiographs.

  At baseline (single study visit)

Secondary Outcomes (2)

• Scoliosis Severity (Cobb Angle)

  At baseline (single study visit)

• Health-Related Quality of Life (PedsQL)

  At baseline (single study visit)

Study Arms (2)

JIA Patients With Scoliosis

Children diagnosed with juvenile idiopathic arthritis (JIA) who have scoliosis, defined by a Cobb angle of ≥10 degrees on standing spinal radiographs. Clinical characteristics, disease activity parameters, and functional assessments including postural and plantar pressure analyses will be evaluated. No intervention will be applied; this group will be observationally assessed.

JIA Patients Without Scoliosis

Children diagnosed with juvenile idiopathic arthritis (JIA) without evidence of scoliosis (Cobb angle \<10 degrees). Participants will undergo the same clinical, laboratory (if applicable), and functional assessments as the scoliosis group. This is an observational group with no intervention.

Eligibility Criteria

• Age: 8 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of children and adolescents aged 8-18 years diagnosed with juvenile idiopathic arthritis (JIA) according to ILAR criteria and followed up at a tertiary pediatric rheumatology center. Participants will be recruited consecutively during routine outpatient visits. The aim of the study is to evaluate the prevalence and severity of scoliosis, as defined by Cobb angle measurements on physical examination and, if necessary, standing spinal radiographs, and to examine its relationship with clinical and functional parameters. Both patients with and without scoliosis will be included in the study.

You may qualify if:

• Age between 8 and 18 years at the time of enrollment
• Diagnosis of juvenile idiopathic arthritis (JIA) according to ILAR criteria
• Written informed consent obtained from parent/legal guardian and assent from the child/adolescent, when appropriate

You may not qualify if:

• Known scoliosis due to non-JIA causes (e.g., congenital vertebral anomalies, neuromuscular disorders, or syndromic scoliosis)
• History of prior spinal surgery or current brace treatment for scoliosis
• History of significant spinal trauma or spinal infection/tumor affecting spinal alignment
• Presence of coexisting chronic conditions that significantly affect posture, gait, or functional testing (e.g., severe neurologic impairment) and may confound assessments
• Inability to undergo required assessments (e.g., inability to stand for radiographs or complete functional measures)

Sponsors & Collaborators

• Istanbul University: lead

MeSH Terms

Conditions

Scoliosis; Arthritis, Juvenile

Condition Hierarchy (Ancestors)

Spinal Curvatures; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Bengisu Menentoğlu

CONTACT

+905359523337; bengisusanisoglu@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: April 1, 2026
• Primary Completion: June 1, 2026
• Study Completion: July 1, 2026
• Last Updated: February 27, 2026

Record last verified: 2026-02