Children With Congenital Diaphragmatic Hernia and the Quality of Their Daily Lives

NCT07432672 | Completed

• 1 other identifier: EK-Nr: 1244/2023
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Congenital diaphragmatic hernia is a rare disease, resulting from a developmental malformation of the diaphragm. Over the last years, management of the affected children has improved significantly. Despite progress in the treatment, it is still related to a high mortality rate. After birth, congenital diaphragmatic hernias are associated with lung hypoplasia as well as pulmonary hypertension which can in turn lead to cardiac dysfunction. Comorbidities as gastroesophageal reflux or respiratory difficulties, such as chronic pulmonary symptoms or repeated respiratory tract infections are common amongst survivors. However, little is known about the health-related quality of life in children after surgical intervention of their diaphragm. Aim: This study aims to obtain information on the health-related quality of life in children with congenital diaphragmatic hernia to improve their future long-term management. Methods: A single-centre prospective study was conducted, examining health-related quality of life of children between five and 18 years of age who were initially treated at the General Hospital of Vienna for congenital diaphragmatic hernia between 2005 and 2019. The validated KIDSCREEN-27 questionnaire was used to assess the health-related quality of life of children with a congenital diaphragmatic hernia, completed by the whole family, including the affected child himself (≥ 8 years old), parents, and siblings. Additionally, a detailed demographic review was obtained.

Conditions

Congenital Diaphragmatic Hernia

Keywords

Quality of life

Outcome Measures

Primary Outcomes (1)

• Primary Outcome Measure

  Primary outcome of this study was HRQoL, assessed using the KIDSCREEN-27 questionnaire . It consists of 27 items covering 5 dimensions (Physical and Psychological Well-Being, Autonomy \& Parent Relations, Social Support \& Peers, and School Environment). Raw scores are transformed into T-scores with a mean of 50 and a standard deviation of 10 based on European normative data. Higher scores indicate better HRQoL. Self- and proxy-reported HRQoL were compared among CDH patients, parents, and siblings. Statistical analyses were performed using SPSS©(V 29.0.2.0), Microsoft Excel© (V16.98), and R (V 4.4.2). Two-sided p-values \<0.05 were considered statistically significant. Continuous variables are presented as mean±standard deviation or median (range), and categorical variables as percentages, based on the number of valid observations (N valid). Group comparisons were conducted using the chi-square test for categorical variables and the two-tailed unpaired t-test for continuous variables.

  2023-2025

Study Arms (3)

Child (CDH patients)

Parents

Siblings

Eligibility Criteria

• Age: 5 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

General Hospital of Vienna

You may qualify if:

• In this study, patients diagnosed with CDH, born between 2005 and 2019 and treated at the Medical University of Vienna at the Comprehensive Center for Pediatrics were included after giving their written consent for this study. Children with CDH, at least eight years old, their parents, and siblings (eight years or older) were asked to complete the questionnaire.
• CDH patients answered the KIDSCREEN-27 childrens version questionnaire (see Appendix) if they were aged eight to 18 years.
• Parents answered the KIDSCREEN-27 parents version questionnaire (see Appendix). If the CDH patients were younger than eight years, only their parents were asked to fill out the questionnaire.
• If siblings were at least eight years old, they were also asked to complete a questionnaire, which is a newly created version of the KIDSCREEN-27 parents version concerning the quality of life of their CDH affected siblings (see Appendix).

Sponsors & Collaborators

• Medical University of Vienna: lead

Study Sites (1)

Medical University of Vienna

Vienna, Vienna, 1090, Austria

Location

MeSH Terms

Conditions

Hernias, Diaphragmatic, Congenital

Condition Hierarchy (Ancestors)

Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hernia, Diaphragmatic; Internal Hernia; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 14 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 9, 2026
• First Posted: February 25, 2026
• Study Start: May 1, 2023
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: February 27, 2026

Record last verified: 2026-02

Locations

AU (1)