Relationship Between Skin Microbiome, Epigenetic Age, and Facial Features in Aging

NCT07431203 | Completed

• 1 other identifier: 2025-A01505-44
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the effect of age on skin microbiome.

Conditions

Healthy Female Volunteer

Keywords

microbiome, skin, epigenetic, aging

Outcome Measures

Primary Outcomes (1)

• Skin microbiome

  single time point

Secondary Outcomes (2)

• skin face measurement

  single time point

• Epigenetic biological age

  single time point

Study Arms (2)

young

between 25 to 35 years old

old

between 55 to 65 years old

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The population to be studied will be women between 25 to 35 years old and between 55 to 65 years old in order to evaluate the relationship between skin collection and saliva sampling and skin measurements.

You may qualify if:

• Healthy subject;
• Sex: female
• Age: 50% having between 25 to 35 years old or 50% between 55 to 65 years old
• Type: Caucasian
• Phototype: I to III on the Fitzpatrick scale
• Subject, having given freely and expressly her informed consent.
• Subject, psychologically able to understand the study related information and to give a written informed consent;
• Subject able to comply with protocol requirements;
• Female of childbearing potential should use a medically accepted contraceptive regimen since at least 12 weeks before the beginning of the study and during all the study.
• Women between 55 to 65 years old should be menopausal (last menstrual period at least 12 months before the screening visit

You may not qualify if:

• Pregnant or nursing woman or planning a pregnancy during the study;
• Subject who had been deprived of their freedom by administrative or legal decision or who is under guardianship;
• Subject who is under guardianship or who is not able to express her consent;
• Subject in a social or sanitary establishment;
• Subject suspected to be non-compliant according to the investigator's judgment;
• Subject having received 6000 euros indemnities for participation in a clinical research in the 12 previous months, including participation in the present study;
• Subject with a condition or receiving a medication which, in the investigator's judgment, put the subject at undue risk or which may interfere with the evaluation;
• Subject suffering from a severe or progressive disease.
• Subject with current cutaneous inflammatory or infectious processes (eg, acne, herpes), abscess, an unhealed wound, or a cancerous or precancerous lesion on the face that could interfere with the evaluation.
• Subject with a tattoo, a scar, moles, acne, too many hairs or anything on the studied zones which might interfere with the evaluation.
• Subject having received injection on the face with botulinum toxin in the year before the screening.
• Subject having received injection of filling product on the face in the year before the screening visit.
• Subject having received injection of mesotherapy in the face in the past 6 months before the screening visit.
• Subject having done a superficial or medium peeling or a superficial scrub on the face within the 2 previous months.
• Subject having received tensor threads on the face in the two years before the screening visit.

Sponsors & Collaborators

• Lesaffre International: lead

Study Sites (1)

Dermscan

Villeurbanne, France

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 18, 2026
• First Posted: February 24, 2026
• Study Start: October 13, 2025
• Primary Completion: December 11, 2025
• Study Completion: December 11, 2025
• Last Updated: February 24, 2026

Record last verified: 2026-02

Locations

FR (1)