NCT07429370

Brief Summary

Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6

participants targeted

Target at below P25 for not_applicable

Timeline
5mo left

Started Jan 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress58%
Jan 2026Dec 2026

Study Start

First participant enrolled

January 1, 2026

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

February 17, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 24, 2026

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

February 24, 2026

Status Verified

February 1, 2026

Enrollment Period

12 months

First QC Date

February 17, 2026

Last Update Submit

February 20, 2026

Conditions

Inactivity, Physical

Keywords

ExerciseMetabolism

Outcome Measures

Primary Outcomes (2)

  • Concentration of metabolites within the plasma

    We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted metabolomic analysis.

    Participants will complete the study within 6 weeks of enrollment.

  • Concentration of proteins within the plasma

    We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted proteomic analysis.

    Participants will complete the study within 6 weeks of enrollment.

Study Arms (2)

>8,500 steps the day prior to exericse

ACTIVE COMPARATOR
Behavioral: Decreased step count

<5,000 steps the day prior to exercise

EXPERIMENTAL
Behavioral: Decreased step count

Interventions

Decreased step countBEHAVIORAL

Subjects will walk less than 5,000 steps

<5,000 steps the day prior to exercise>8,500 steps the day prior to exericse

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • between the ages of 18-30 years old

You may not qualify if:

  • free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders)
  • do not take medications related to metabolism (i.e., statins, metformin, GLP-1 agonists)
  • free from orthopedic limitations (including any artificial joints)
  • currently smoke or participate in other forms of tobacco use.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Concordia University of Wisconsin

Mequon, Wisconsin, 53093, United States

RECRUITING

MeSH Terms

Conditions

Sedentary BehaviorMotor Activity

Condition Hierarchy (Ancestors)

Behavior

Central Study Contacts

Kevin J Gries, PhD

CONTACT

2622434293kevin.gries@cuw.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 17, 2026

First Posted

February 24, 2026

Study Start

January 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

February 24, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

Locations

US(1)