Trials Sponsors Conditions Drugs Pricing

Conditions

Stain Removal Efficacy

Keywords

tooth whitening; extrinsic stain; whitening toothpaste; Macpherson Lobene Stain Index; dentifrice; stain removal

Outcome Measures

Primary Outcomes (1)

Change in Extrinsic Tooth Stain (Total Stain Score)
Mean change in total extrinsic stain score measured on the labial surfaces of the 12 anterior teeth using the Macpherson Modification of the Lobene Stain Index, combining stain intensity and stain area scores.
Baseline to Day 42

Secondary Outcomes (1)

Change in Stain Intensity and Stain Area Scores
Baseline to Days 7, 14, 28, and 42

Other Outcomes (1)

Subject-Reported Whitening and Sensory Assessments
Baseline and Days 7, 14, 28, and 42

Study Arms (2)

Test Toothpaste

EXPERIMENTAL

Investigational whitening toothpaste evaluated for removal of extrinsic tooth stain over 42 days of use.

Other: Whitening Test Dentifrice (Code 826)

Sodium Fluoride Control Dentifrice

OTHER

Non-whitening toothpaste used twice daily for two minutes per brushing for six weeks.

Other: Control dentifrice (Code 378)

Interventions

Whitening Test Dentifrice (Code 826)Other

Whitening toothpaste used twice daily for two minutes per brushing for six weeks.

Test Toothpaste

Control dentifrice (Code 378)Other

Non-whitening toothpaste used twice daily for two minutes per brushing for six weeks.

Sodium Fluoride Control Dentifrice

Eligibility Criteria

Age18 Years - 65 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Adults 18-65 years in good general health
Mean MLSI score ≥1.5 on labial surfaces of at least 8 of 12 anterior teeth

Sponsors & Collaborators

Church & Dwight Company, Inc.
Industrylead

Study Sites (1)

Salus Research, Inc.

Fort Wayne, Indiana, 46825, United States

Study Officials

Annahita Ghassemi, PhD
Church & Dwight, Inc.
STUDY DIRECTOR

Enrollment

118 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: TRIPLE
Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: OTHER
Intervention Model: PARALLEL
Sponsor Type: INDUSTRY
Responsible Party: SPONSOR

Study Record Dates

First Submitted

February 19, 2026

First Posted

February 24, 2026

Study Start

August 8, 2024

Actual (reported)

Extrinsic Tooth Whitening Evaluation of a Whitening Toothpaste

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Other Outcomes (1)

Study Arms (2)

Test Toothpaste

Sodium Fluoride Control Dentifrice

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Other Outcomes (1)

Study Arms (2)

Test Toothpaste

Sodium Fluoride Control Dentifrice

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations