NCT07427290

Brief Summary

The goal of this clinical trial is to evaluate whether a combined neuromuscular rehabilitation program improves static balance, jump performance, and ankle muscle strength in athletes with chronic ankle instability. It will also examine whether the addition of kinesio taping provides additional effects compared with exercise alone. The main questions it aims to answer are: Does a six-week balance and strength exercise program improve static postural control in athletes with chronic ankle instability? Does the rehabilitation program improve countermovement jump performance, drop jump performance, and ankle inversion and eversion muscle strength? Does adding kinesio taping to the exercise program lead to greater improvements in balance, jump performance, and ankle muscle strength compared with exercise alone? Researchers will compare three groups: an exercise group, an exercise plus kinesio taping group, and a control group, to evaluate the effects of the rehabilitation program and the potential additional effects of kinesio taping. Participants will: Take part in a supervised rehabilitation program three times per week for six weeks (intervention groups). Perform balance training on a wobble board and strength exercises using elastic resistance bands. Receive kinesio taping before each rehabilitation session if assigned to the taping group. Undergo assessments before and after the intervention, including force-plate measurements of static balance, countermovement jump and drop jump performance, and dynamometer measurements of ankle inversion and eversion muscle strength.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 20, 2024

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 2, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 2, 2025

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

February 11, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

February 23, 2026

Completed
Last Updated

September 14, 2026

Status Verified

September 1, 2026

Enrollment Period

5 months

First QC Date

February 11, 2026

Last Update Submit

September 9, 2026

Conditions

Keywords

Balance TrainingKinesio TapingStrength TrainingChronik Ankle InstabilityStatic BalanceVertical JumpDrop Jump

Outcome Measures

Primary Outcomes (2)

  • Change in Static Balance Measured by Center of Pressure Ellipse Area

    Static balance will be assessed using a force plate by analyzing center of pressure (COP) parameters, specifically the ellipse area. Measurements will be performed in a single-leg stance position under two conditions: eyes open and eyes closed. Smaller COP ellipse area values indicate better postural control.

    From baseline assessment to post-intervention assessment after 6 weeks

  • Countermovement Jump (CMJ) Height

    Countermovement jump (CMJ) performance was assessed using the Leonardo Mechanograph GRFP STD force platform (Novotec Medical GmbH, Pforzheim, Germany). Participants performed bilateral countermovement jumps, and jump height was automatically calculated by the manufacturer's software and recorded in meters (m). Three valid trials were performed, separated by approximately 60 seconds of rest, and the highest jump height was used for statistical analysis. Higher values indicated better vertical jump performance.

    Baseline and after the 6-week intervention

Secondary Outcomes (3)

  • Ankle Inversion and Eversion Muscle Strength

    Baseline and after the 6-week intervention

  • Drop Jump Contact Time

    Baseline and after the 6-week intervention

  • Reactive Strength Ratio (RSR)

    Baseline and after the 6-week intervention

Study Arms (3)

Combined Rehabilitation Group

EXPERIMENTAL

Participants in this group received a combined rehabilitation program consisting of balance and strength exercises together with kinesio taping applied to the ankle. The intervention was performed according to a standardized protocol for improving balance and ankle stability

Other: Exercise Program with Kinesio Taping

Exercise Only Group

EXPERIMENTAL

Participants in this group received only the exercise program (balance and strength) without kinesio taping. The exercises were identical to those used in the combined group and followed the same duration and frequency.

Other: Balance and Strength Exercise Program

Control Group

NO INTERVENTION

Participants in this group did not receive any structured rehabilitation intervention during the study period. They continued their usual daily activities without additional therapeutic exercises or kinesio taping.

Interventions

The same six-week balance and strength rehabilitation program as in the Exercise Group, combined with Kinesio Taping applied to the ankle before each training session. Taping was applied by a certified physiotherapist using a standardized technique to enhance proprioceptive input and neuromuscular activation.

Combined Rehabilitation Group

A structured rehabilitation program consisting of balance training on a wobble board and ankle strengthening exercises using Thera-Band. Sessions were performed three times per week for six weeks under physiotherapist supervision. Exercises included single-leg balance tasks with progressive difficulty and strengthening exercises targeting dorsiflexion, plantarflexion, inversion, and eversion.

Exercise Only Group

Eligibility Criteria

Age18 Years - 25 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may not qualify if:

  • History of musculoskeletal surgery. Presence of orthopedic conditions such as lower-limb fractures. Any musculoskeletal injury within the 3 months preceding the study. Known neurological disorders that could influence balance performance. Known vestibular disorders that could influence balance performance.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sport University of Tirana

Tirana, 1001, Albania

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Physiotherapist, PhD Candidate

Study Record Dates

First Submitted

February 11, 2026

First Posted

February 23, 2026

Study Start

November 20, 2024

Primary Completion

May 2, 2025

Study Completion

May 2, 2025

Last Updated

September 14, 2026

Record last verified: 2026-09

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared due to confidentiality considerations and institutional data protection policies. Only aggregated, anonymized results will be reported in publications.

Locations