Impact of Shift Work on Glucose and Lipid Metabolism of Hospital Workers

NCT07426211 | Not Yet Recruiting

• 1 other identifier: 3001777
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of the study is to evaluate circadian glucose, activity and dietary rhythms, as well as metabolic and cardiovascular risk associated with night shift work, sleep quality and well-being in a cohort of hospital staff, comparing employees with night shifts to employees without night shifts.

Conditions

Glucose and Lipid Metabolism; Chronodisruption; Shift Work Disorder

Keywords

Shift work; Circadian clocks; Nutrition; Glucose metabolism; Lipid metabolism

Outcome Measures

Primary Outcomes (1)

• Mean 24-hour glucose levels and mean night glucose levels

  Mean 24-hour glucose \[mg/dl\] and mean night glucose \[mg/dl\] assessed by continuous glucose monitoring (CGM)

  2 weeks

Secondary Outcomes (27)

• Body weight

  2 weeks

• Body Mass Index (BMI)

  2 weeks

• Blood pressure

  2 weeks

• Glycemic variability

  2 weeks

• Eating time

  2 weeks

Study Arms (2)

Group A

Night workers

Group B

Individuals not working night shifts

Eligibility Criteria

• Age: 18 Years - 67 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospital workers

You may qualify if:

• Aged between 18 and 67
• Male or female
• Currently employed
• Body-Mass-Index (BMI) \<40 kg/m2
• Working hours ≥28 hours/week
• Employees working night shifts (group A): (1) Working night shifts for \>1 year, (2) at least two night shifts within the 2-week observation period
• Employees not working night shifts (group B): No night shifts for \>1 year
• Capable of giving consent
• Health insurance
• Good knowledge of German

You may not qualify if:

• Pregnancy and breastfeeding
• Special diets, e.g. intermittent fasting
• Severe acute or chronic illnesses, e.g. type 1 diabetes mellitus, liver or kidney disease, heart attack within the last 6 months, stroke or systemic infections, current cancer or cancer within the last 2 years
• Bariatric surgery
• Hereditary or acquired blood clotting disorders
• Severe mental illnesses, e.g. depression, addiction or eating disorders (individual assessment by study staff, if necessary after consultation with a doctor)
• Holiday in a different time zone (≥ 2 hours time difference) one month before study participation or within the 2-week observation phase
• Participation in another study that could influence the results of the current study
• Special drug therapies that could influence the study results (individual assessment by study staff, if necessary after consultation with a physician)
• Physical or mental difficulties in understanding and following instructions from study staff

Sponsors & Collaborators

• Olga Ramich (formerly Pivovarova): lead
• Charite University, Berlin, Germany: collaborator

Study Sites (2)

Charité-Universitaetsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine (CCM/CVK)

Berlin, Germany

Location

Pflegebereiche CC07 Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum

Berlin, Germany

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood, hair roots

Central Study Contacts

Olga Ramich, Prof. Dr.

CONTACT

+49 33200 882749; olga.ramich@dife.de

Anna Merckens

CONTACT

+49 33200 882459; anna.merckens@charite.de

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof., Department Head

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: February 23, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2028
• Last Updated: May 5, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

DE (2)