The Effect of Oral Care With Propolis in COPD Patients

NCT07426198 | Completed

• 1 other identifier: 73
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The study was conducted in intensive care units and included patients diagnosed with COPD. The study was conducted with a total of 60 COPD patients, 30 in the intervention group and 30 in the control group. Individuals in the intervention group were given an oral care protocol containing propolis for 15 days, in addition to the clinic's standard oral care protocol. The control group continued to receive standard oral care. Oral mucosa was assessed on days 1, 7 and 15.

Conditions

Oral Mucositis

Keywords

propolis; COPD; nursing; oral mucositis

Outcome Measures

Primary Outcomes (2)

• World Health Organization Oral Mucositis Scoring Index

  The WHO Oral Mucositis Scoring Index rates the severity of mucositis on a scale of 0 to 4. Grade 0 indicates no mucositis; grade 1 indicates mild mucositis, grade 2 indicates moderate mucositis, and grades 3 and 4 indicate severe mucositis.

  The 1st, 7th, and 15th days were evaluated.

• Oral Assessment Guide

  Each assessment area is scored on a scale of 1, 2, or 3 points based on the severity of changes in the oral mucosa. All points obtained from the eight areas are added together to calculate the Total Oral Mucosa Score (OMP). An increase in the total score indicates worsening of oral mucosal damage and associated clinical symptoms. The lowest possible score from the guide is 8, and the highest is 24.

  The 1st, 7th, and 15th days were evaluated.

Study Arms (2)

Propolis Oral Care Group

EXPERIMENTAL

Individuals in the intervention group were given an oral care protocol containing propolis for 15 days, in addition to the clinic's standard oral care protocol.

Other: Oral care with propolis

Control group

NO INTERVENTION

The control group continued to receive standard oral care.

Interventions

Oral care with propolis OTHER

Individuals in the intervention group were given an oral care protocol containing propolis for 15 days, in addition to the clinic's standard oral care protocol.

Propolis Oral Care Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 years or older,
• diagnosed with COPD,
• no oral mucositis at the start of the study,
• no known allergy to bees or bee products,
• able to speak and understand Turkish and communicate effectively,
• conscious,
• without any psychiatric illness,
• without any mental or physical disability that would prevent them from answering questions,
• individuals who volunteered to participate in the study were included in the study.

You may not qualify if:

• individuals with a cancer diagnosis,
• individuals receiving immunosuppressive therapy,
• individuals receiving mechanical ventilation support,
• individuals with altered consciousness or acute confusion,
• individuals who did not volunteer to participate in the study were excluded from the research.

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes University

Talas, Kayseri, 38039, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Stomatitis; Pulmonary Disease, Chronic Obstructive

Interventions

Propolis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Resins, Plant; Biopolymers; Polymers; Macromolecular Substances; Plant Exudates; Biological Products; Complex Mixtures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: instructor

Study Record Dates

• First Submitted: February 16, 2026
• First Posted: February 23, 2026
• Study Start: January 1, 2025
• Primary Completion: June 10, 2025
• Study Completion: June 10, 2025
• Last Updated: February 23, 2026

Record last verified: 2026-02

Locations

TU (1)