Brillouin Scanning in Cataractous Eyes

NCT07425626 | Active Not Recruiting

• 1 other identifier: Brillouin Cataract
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

To provide first results for biomechanical properties of cataractous lenses via Brillouin microscopy and correlations between LOCS III grading, cataractous lens scans from optical coherence tomography (OCT), and intraoperative phacoemulsification energy.

Conditions

Cataract

Keywords

Cataract; Brillouin-Microscopy; Lens Stiffening

Outcome Measures

Primary Outcomes (1)

• Brillouin shift/stiffness metrics

  Correlation between Brillouin shift/stiffness metrics and LOCS III grading, OCT lens opacification scans/metrics and and intraoperative phacoemulsification energy

  24 months

Secondary Outcomes (1)

• Repeatability of Brillouin-Microscopy Measurements

  24 months

Study Arms (1)

Cataract Patients

50 Patients with Cataract

Device: Brillouin-Microscopy

Interventions

Brillouin-Microscopy DEVICE

A Brillouin scattering microscopy system (Brillouin Optical Scanning System, Intelon Optics, Boston, MA) will be employed to acquire data. The emission spectrum of the single-frequency tunable laser is fixed at approximately 780 nm near-infrared wavelength. Polarization optics direct the laser beam to the eye and channel backscattered light to a single-mode fiber at the human interface, where the laser light is transmitted over a polarization-maintaining single-mode fiber. To achieve a free-spectral range (FSR) of approximately 16 GHz, a resolution of approximately 0.3 GHz, and an extinction efficiency of -65 dB, the spectrometer employs dual-stage VIPA (virtually imaged phase arrays) etalons. The cornea's optical power is 3-5 mW, which is significantly lower than the utmost permissible exposure level as defined by the American National Standards Institute (ANSI).

Cataract Patients

Eligibility Criteria

• Age: 21 Years - 105 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

50 cataract patients with predominantly nuclear cataract

You may qualify if:

• Men and women aged above 21 years
• Normal ophthalmic findings except previous surgery or conditions that impact corneal optical quality such as trauma and corneal scars
• Willing to sign informed consent before measurements
• Presence of nuclear cataract according to LOCS III grading and planned cataract surgery

You may not qualify if:

• Any of the following will exclude a subject from the study:
• Patients with inadequate corneal imaging or corneal scarring that would impact results
• Patients with active ocular infections or inflammatory conditions
• Patients that suffered an eye trauma according to their medical history
• Patients with fixational problems (e.g., nystagmus) or with any medical condition that could interfere with the measurements
• Pregnancy (pregnancy test will be performed in women of reproductive age)

Sponsors & Collaborators

• Prim. Prof. Dr. Oliver Findl, MBA: lead

Study Sites (1)

Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna

Vienna, 1140, Austria

Location

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens Diseases; Eye Diseases

Study Officials

• Oliver Findl, Prof., Dr.

  Vienna Institute for Research in Ocular Surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 13, 2026
• First Posted: February 23, 2026
• Study Start: March 11, 2025
• Primary Completion: February 1, 2026
• Study Completion: June 1, 2026
• Last Updated: February 23, 2026

Record last verified: 2026-02

Locations

AU (1)