Evaluation of Yoga and Conventional Physical Exercise for Pain and Quality of Life in Women With Endometriosis: A Randomized Clinical Trial

NCT07424859 | Completed

• 2 other identifiers: 17755198728884
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

two-arm randomized parallel-group trial comparing an 8-week online yoga program versus a conventional physical exercise program.

Conditions

Endometriosis; Chronic Pain; Dysmenorrhea; Dyspareunia

Outcome Measures

Primary Outcomes (2)

• Change in dysmenorrhea intensity (VAS 0-10)

  Difference in dysmenorrhea intensity measured on a 0-10 visual analogue scale (VAS), comparing yoga and physical exercise groups. Higher scores indicate more intense pain.

  Baseline to week 8

• Change in dysmenorrhea intensity (VAS 0-10)

  Difference in dysmenorrhea intensity measured on a 0-10 visual analogue scale (VAS), comparing yoga and physical exercise groups. Higher scores indicate more intense pain.

  Baseline (week 0) to week 8

Study Arms (2)

Arm 1 yoga

EXPERIMENTAL

Participants assigned to the yoga arm received eight weekly 30-minute online group sessions delivered via videoconference by trained instructors. Each session included meditation, pranayama breathing techniques and a standardized sequence of seated and standing postures targeting relaxation, body awareness, flexibility and pelvic/lumbopelvic muscle balance

Other: YOGA

arm 2 - physical exercise

ACTIVE COMPARATOR

Participants assigned to the physical exercise arm received eight weekly 30-minute online group sessions focusing on functional strengthening and stretching of the hip and pelvis, delivered via videoconference by physical educators or physiotherapists.

Other: physical exercise

Interventions

YOGA OTHER

The Yoga program incorporated meditation, pranayama breathing techniques, and physical postures aimed at relaxation, body awareness, and improvement of flexibility and muscle balance

Arm 1 yoga

physical exercise OTHER

The physical exercise protocol included joint warm-up, strengthening and stabilization exercises for the pelvis and hip, and stretching for mobility and muscle relief, focusing primarily on functional and resistance-based movements rather than aerobic or traditional weight-training components

arm 2 - physical exercise

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Women aged 18 to 45 years
• Confirmed diagnosis of endometriosis by pelvic magnetic resonance imaging, transvaginal ultrasound with bowel preparation, or laparoscopy with histological confirmation
• Presence of endometriosis-related pain (dysmenorrhea, deep dyspareunia, non-cyclical pelvic pain, dyschezia, or cyclical dysuria) with minimum intensity ≥3 on a 0-10 scale
• Ability to participate in online sessions via videoconference
• Provision of written informed consent

You may not qualify if:

• Active malignancy
• Known infectious or inflammatory disease
• Contraindications to practicing physical activity
• Scheduled surgery during the 8-week study period
• Initiation of new hormonal therapy during the study period
• Age older than 45 years
• Refusal or inability to provide informed consent

Sponsors & Collaborators

• Beneficência Portuguesa de São Paulo: lead

Study Sites (1)

Beneficencia Portuguesa de Sao Paulo

São Paulo, São Paulo, 01323001, Brazil

Location

Related Publications (1)

• Murayama BAR, Mello PLP, Valdívia MS, et al. Evaluation of yoga in controlling pain symptoms and quality of life in women with endometriosis: a randomized clinical trial. Journal of Integrative Gynecology. 2026;15(2):123-135.

  RESULT

MeSH Terms

Conditions

Endometriosis; Chronic Pain; Dysmenorrhea; Dyspareunia

Interventions

Yoga; Exercise

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Menstruation Disturbances; Pathologic Processes; Pelvic Pain; Genital Diseases, Male; Sexual Dysfunction, Physiological; Male Urogenital Diseases; Sexual Dysfunctions, Psychological; Mental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Spiritual Therapies; Exercise Movement Techniques; Physical Therapy Modalities; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PHD

Model Details: The yoga program consisted of eight 30-minute sessions delivered once weekly via Zoom or Google Meet. Sessions included an initial brief meditation, followed by pranayama techniques (e.g., Prana Shuddhi, Chandra Bhedana, Bhramari) and postures such as Sukhasana, Paschimottanasana, Gomukhasana, Baddha Konasana, Tadasana, Adho Mukha Svanasana, Anjaneyasana and Eka Pada Rajakapotasana, ending with Savasana. Participants were advised not to engage in other structured physical activity during the intervention period; Participants assigned to the physical exercise arm received eight weekly 30-minute online group sessions focusing on functional strengthening and stretching of the hip and pelvis, delivered via videoconference by physical educators or physiotherapists.

Study Record Dates

• First Submitted: February 16, 2026
• First Posted: February 20, 2026
• Study Start: March 1, 2022
• Primary Completion: April 10, 2025
• Study Completion: July 31, 2025
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)