Comparison Between Two Drugs in Sedation of Upper GI Endoscopy

NCT07423676 | Not Yet Recruiting

• 1 other identifier: Sedation in GI endoscopy
• Study Type: observational
• Target: 52
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs Secondary outcome :

• Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
• Hemodynamics (MAP,HR) \& oxygen saturation
• Drug side effects (nausea,vomitting,agitation)
• Endoscopist satisfaction

Conditions

Sedation During GI Endoscopy

Keywords

Sedation

Outcome Measures

Primary Outcomes (3)

• Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy

  Time of sedation :is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

  Baseline

• Comparison time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy

  Time of sedation:is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

  Baseline

• Comparison of time of sedation between ketamine Dexametomidine g

  • Time of sedation :is the time to reach score 5 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .

  Basline

Study Arms (1)

Ketamine dexmetamodine and propofol midazolam

Eligibility Criteria

• Age: 21 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients not more than 60 years old with BMI \< 35 kg/m2

You may qualify if:

• Patient acceptance
• Adults aged 21-60 years.
• Both sexes
• BMI\<35 kg/m2
• ASA physical status :I\& II
• Patients Undergoing Gastrointestinal endoscopy
• Duration \<30mintues

You may not qualify if:

• Known allergy to any of the study drugs
• Unstable Cardiovascular disease
• Moderate to severe respiratory diseases

Sponsors & Collaborators

• Zagazig University: lead

Related Publications (2)

• Rey JF. Sedation for upper gastrointestinal endoscopy: as much as possible, or without? Endoscopy. 1996 Mar;28(3):308-9. doi: 10.1055/s-2007-1005460. No abstract available.

  PMID: 8781797 BACKGROUND

• Sachdeva A, Bhalla A, Sood A, Duseja A, Gupta V. The effect of sedation during upper gastrointestinal endoscopy. Saudi J Gastroenterol. 2010 Oct-Dec;16(4):280-4. doi: 10.4103/1319-3767.70616.

  PMID: 20871194 BACKGROUND

Study Officials

• Doaa Mohamed Farid, MD

  Doaa mohamed Farid

  PRINCIPAL INVESTIGATOR

• Rehab Abdalla Wahdan, MD

  Rehab Abdalla Wahdan

  STUDY DIRECTOR

• Olfat Monium Abraham, MD

  Olfat abdelmonium Ebrahim

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Esam Hamad, Register

CONTACT

+201095529439; tahawy188@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2026
• First Posted: February 20, 2026
• Study Start: March 1, 2026
• Primary Completion: May 2, 2026
• Study Completion: May 2, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share