NCT07423416

Brief Summary

Long-term observation has shown that patients with visual impairment often develop cognitive impairments. Due to the fact that patients who are planning to undergo corneal transplantation may have initial cognitive deficits, assessing cognitive function is an important aspect of work for both the anesthesiologist and the operating surgeon. Given the high significance of assessing cognitive function after anesthesia in ophthalmic surgery patients, it is relevant to adapt and validate the Russian version of the MoCA Blind test for subsequent use in clinical practice.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Mar 2026

Shorter than P25 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress32%
Mar 2026Jan 2027

First Submitted

Initial submission to the registry

February 12, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 20, 2026

Completed
9 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 30, 2027

Last Updated

February 20, 2026

Status Verified

February 1, 2026

Enrollment Period

10 months

First QC Date

February 12, 2026

Last Update Submit

February 19, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • postoperative neurocognitive disorders

    Postoperative neurocognitive disorders were identified by comparing the results of neuropsychological tests performed before surgery and on the 90th day after surgery. An individual Z-score was used for each domain of the test.

    From the moment of inclusion in the study until the end of treatment 90 days later

Interventions

Neurocognitive testingDIAGNOSTIC_TEST

The psychometric properties of the Russian version of the MoCA Blind scale were evaluated according to the following parameters: reliability (reproducibility and internal consistency), validity (content and construct), and sensitivity.

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Russian-speaking patients with corneal pathology who are planning a corneal transplant in the future

You may qualify if:

  • patients with corneal pathology, including burns, ulcers, dystrophies, and keratoectasia, as well as those with a history of corneal injuries
  • physical status of I-III on the ASA scale.

You may not qualify if:

  • children
  • patients with sensorineural hearing loss
  • patients with chronic cerebrovascular disorders
  • patients with initially high levels of anxiety and depressive symptoms
  • patients with severe cognitive impairments.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Central Study Contacts

Alexandr Alexandr Romanov

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Year
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of the Department of Anesthesiology and Intensive Care

Study Record Dates

First Submitted

February 12, 2026

First Posted

February 20, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

January 30, 2027

Last Updated

February 20, 2026

Record last verified: 2026-02