Assessment of Licorice Extract as an Adjunctive Therapy to Mechanical Debridement in Stage II Periodontitis

NCT07422883 | Completed

• 1 other identifier: A0204023OM
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

To assess the clinical effectiveness of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement in stage II periodontitis patients. To assess the impact of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement on the level of interleukin-6 in the GCF in stage II periodontitis patients .

Conditions

Interleukin 6

Outcome Measures

Primary Outcomes (1)

• To assess the clinical effectiveness of the locally delivered licorice extract gel as an adjunctive therapy to mechanical debridement in Stage II periodontitis patients

  Patients diagnosed with periodontitis underwent meticulous full-mouth debridement in a single session using ultrasonic scalers and site-specific Gracey curettes. All participants were instructed to maintain optimal oral hygiene practices without any additional prescribed therapeutic agents during the study.In the study group, a standardized licorice extract gel containing 5% glycyrrhizin was applied to selected periodontal pockets. These targeted sites were gently irrigated with normal saline and left for 10 minutes to achieve hemostasis. The gel was then applied using a plastic syringe fitted with a wide-gauge needle to facilitate effective delivery . After proper isolation, the needle tip was inserted into the base of the pocket, and the gel was dispensed slowly while gradually withdrawing the needle to ensure uniform distribution along the pocket depth. This application was repeated twice weekly for six weeks, after ensuring the absence of local deposits on the treated tooth .

  samples will be collected at Base line then after 3 months by using periopaper strips

Secondary Outcomes (1)

• To assess the impact of the locally delivered licorice extract gel as an adjunctive therapy to mechanical debridement on the level of IL-6 in the GCF in Stage II periodontitis patients.

  samples are collected at baseline and after 3 months using peiopaper strips

Study Arms (3)

Ten subjects with healthy periodontium will be selected for this group.

NO INTERVENTION

Mechanical debridement will be performed for 20 stage II periodontitis patients.

PLACEBO COMPARATOR

Other: Mechanical Debridement

Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local ap

EXPERIMENTAL

Drug: Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel.

Interventions

Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel. DRUG

Adequate amount of prepared licorice gel will be inserted into the selected periodontal pockets.

Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local ap

Mechanical Debridement OTHER

• Mechanical debridement will be performed using suitable ultrasonic and hand instruments

Mechanical debridement will be performed for 20 stage II periodontitis patients.

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with Stage II Periodontitis (mainly horizontal bone loss with maximum probing depth ≤ 5 mm and with 3-4 mm clinical attachment loss).
• Age range (30 - 50) years.
• Good compliance with the plaque control instructions following initial therapy.
• Availability for follow up and maintenance program.

You may not qualify if:

• Smoking.
• Systemic diseases which could influence the outcome of the therapy (According to Cornell Medical Index-Health Questionnaire).
• Pregnant and lactating females.
• Vulnerable groups of patients' e.g (prisoners, disabled patients and decisionally impaired individuals).

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura university

Al Mansurah, Egypt

Location

Study Officials

• Mohamed m Anes, Professor

  Faculty of dentistry - Mansoura university

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 29, 2026
• First Posted: February 20, 2026
• Study Start: February 1, 2025
• Primary Completion: July 15, 2025
• Study Completion: August 12, 2025
• Last Updated: February 20, 2026

Record last verified: 2026-01

Locations

EG (1)