NCT07422649

Brief Summary

This retrospective cohort study examined clinical outcomes in patients who underwent mechanical thrombectomy for acute ischemic stroke under general anesthesia or sedoanalgesia. Patient data from 2014 to 2018 were obtained from hospital medical records. Mortality and neurological outcomes were compared between anesthesia groups.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
481

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2026

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 5, 2026

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 20, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

April 1, 2026

Completed
3 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 4, 2026

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 5, 2026

Completed
Last Updated

April 8, 2026

Status Verified

April 1, 2026

Enrollment Period

3 days

First QC Date

February 5, 2026

Last Update Submit

April 7, 2026

Conditions

Acute Ischemic Stroke

Keywords

Acute Ischemic StrokeMechanical ThrombectomyGeneral AnesthesiaSedoanalgesia

Outcome Measures

Primary Outcomes (1)

  • All-Cause Mortality

    Comparison of all-cause mortality between patients undergoing mechanical thrombectomy under general anesthesia and sedoanalgesia.

    During index hospitalization and at 3 months post-procedure

Secondary Outcomes (12)

  • NIHSS Score

    Baseline, 4 hours, 24 hours post-procedure

  • Modified Rankin Scale (mRS)

    Immediately after completion of the angiographic procedure and at 3 months after the initial thrombectomy

  • TICI Reperfusion Grade

    Immediately after completion of the angiographic procedure and at 3 months after the initial thrombectomy.

  • Near-Infrared Spectroscopy (NIRS) Values

    During index hospitalization and at 3 months post-procedure

  • Bispectral Index (BIS) Values

    During the procedure

  • +7 more secondary outcomes

Study Arms (2)

General Anesthesia Group

Patients who underwent mechanical thrombectomy under general anesthesia, based on anesthesia records.

Other: General Anesthesia

Sedoanalgesia Group

Patients who underwent mechanical thrombectomy under sedoanalgesia, based on anesthesia records.

Other: Sedoanalgesia

Interventions

General AnesthesiaOTHER

Patients who underwent mechanical thrombectomy under general anesthesia, based on anesthesia records.

General Anesthesia Group
SedoanalgesiaOTHER

Patients who underwent mechanical thrombectomy under sedoanalgesia, based on anesthesia records.

Sedoanalgesia Group

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population consisted of adult patients with acute ischemic stroke who underwent mechanical thrombectomy at the University of Health Sciences Bakirkoy Dr. Sadi Konuk Training and Research Hospital between 2014 and 2018. Patients were treated within 6 hours of symptom onset and achieved successful angiographic reperfusion. Based on anesthesia records, patients were categorized according to anesthesia management as general anesthesia or sedoanalgesia.

You may qualify if:

  • Age ≥18 years
  • Acute ischemic stroke due to large vessel occlusion (MCA M1)
  • Mechanical thrombectomy performed within 6 hours of symptom onset
  • Pre-procedural TICI score 0-1

You may not qualify if:

  • Age ≥100 years
  • APACHE II score of 25 or higher
  • Glasgow Coma Scale score below 10
  • Requirement for endotracheal intubation before the procedure
  • Patients discharged from the procedure to the intensive care unit while intubated
  • Time from symptom onset to procedure exceeding 6 hours

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fatma Acil

Diyarbakır, Outside of the US, 21070, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Ischemic Stroke

Interventions

Anesthesia, General

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

AnesthesiaAnesthesia and Analgesia

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

February 5, 2026

First Posted

February 20, 2026

Study Start

April 1, 2026

Primary Completion

April 4, 2026

Study Completion

April 5, 2026

Last Updated

April 8, 2026

Record last verified: 2026-04

Locations

TU(1)