Overlooked Barrier To Discontinuing Bont-A Therapy

NCT07422428 | Completed

• 1 other identifier: SDU-FTR-HALENUR-YAMAN-00000001
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate patient adherence to botulinum toxin (BoNT-A) treatment and identify the factors contributing to its discontinuation. This retrospective cohort study analyzed the medical records of patients who received at least one botulinum toxin treatment for post-stroke spasticity (PSS) from 2012 to 2024. Eighty-one enrolled patients responded to structured questions about their reasons for not consistently continuing BoNT-A treatment.

Conditions

Post Stroke Spastic Hemiplegia

Keywords

Botulinum toxin, Spasticity, Stroke, Treatment Discontinuation

Outcome Measures

Primary Outcomes (2)

• Primary Outcome

  Most PSS patients received only one BoNT-A injection over 12 years

  2012-2024

• Primary Outcome

  The primary reason cited for discontinuing BoNT-A therapy was a lack of awareness about the necessity of ongoing treatment.

  2012-2024

Interventions

provide information by phone OTHER

Previous studies did not question why patients thought they did not benefit from the injection. For example, the expectations of patients who said they did not benefit were excessive.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients were recruited from outpatient and inpatient clinics at a university's Physical Medicine and Rehabilitation department.

You may qualify if:

• included chronic-phase ischemic or hemorrhagic stroke and spasticity in the upper and/or lower limbs.

You may not qualify if:

• Patients younger than 18 years, those who had passed away, and those who could not be reached by phone were excluded from the study.

Sponsors & Collaborators

• Suleyman Demirel University: lead

Study Sites (1)

Süleyman Demirel University Faculty of Medicine Hospital

Isparta, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Muscle Spasticity; Stroke

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 12 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant doctor

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 20, 2026
• Study Start: September 23, 2024
• Primary Completion: February 10, 2025
• Study Completion: April 5, 2025
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)