IV Lidocaine Infusion Versus Placebo for Pain Control in Staging Laparoscopy Cases

NCT07419815 | Active Not Recruiting

• 1 other identifier: IRB-24-24
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

IV lidocaine infusion is being used as an analgesic adjunct, since we are a opioid depleted country we are using lidocaine to decrease opioid consumption and avoid the side effects such nausea, vomiting and respiratory depression associated with morphine consumption. We have given the option of rescue analgesia to the anesthetist if the clinical scenario demands.

Conditions

Side Effects of Opoid Consumption

Keywords

mean pain score; acute pain; mean morphine consumption

Outcome Measures

Primary Outcomes (1)

• Mean pain score

  Pain score using numeric rating scale (NRS) will be noted at arrival, 2 hours

  2 hours

Secondary Outcomes (1)

• Mean morphine consumption

  till discharge from post anesthesia care unit

Study Arms (2)

Group A

EXPERIMENTAL

This arm will receive Lidocaine infusion

Drug: Lidocaine Infusion

Group B

PLACEBO COMPARATOR

This arm will receive placebo

Drug: Normal Saline

Interventions

Lidocaine Infusion DRUG

Patients in Group A will be given intravenous lidocaine (2.0 %) first as a bolus of 1mg/kg over 3 minutes before incision and then as a continuous infusion of 2mg/kg/hour (maximum dose 200mg/hour)

Group A

Normal Saline DRUG

patients in Group B will be given normal saline bolus and infusion at same rate during surgery

Group B

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 to 60 years.
• American Society of Anesthesiologists grade 1 and 2 patients.
• Both Genders
• Elective staging Laparoscopy

You may not qualify if:

• Patients allergic to lidocaine.
• Patients refusal.
• Patients having a history of chronic pain.
• Patients already using opioids for pain control
• Use of suxamethonium.
• Procedures taking longer than 60 minutes

Sponsors & Collaborators

• Shaukat Khanum Memorial Cancer Hospital & Research Centre: lead

Study Sites (1)

Shaukat Khanam Memorial Cancer Hospital & Research Centre

Lahore, Punjab Province, 54470, Pakistan

Location

MeSH Terms

Conditions

Acute Pain

Interventions

Saline Solution

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Crystalloid Solutions; Isotonic Solutions; Solutions; Pharmaceutical Preparations

Study Officials

• Dr. Almas Iqbal, MBBS, MBA, FRCA

  Shaukat Khanam Memorial Cancer Hospital & Research Centre

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized controlled trial. One group will recieve lidocaine infusion and other group will reciev placebo. option of rescue analgesia will be given to both groups if needed.

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: February 19, 2026
• Study Start: December 3, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: February 19, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)