Kinesthetic Exercises on Adults

NCT07417748 | Active Not Recruiting

• 1 other identifier: 2026/02
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to determine the possible effect of kinesthetic brain exercises on cognitive function in patients with heart failure. The study will include 40 volunteer individuals aged 30-65 years who have been diagnosed with heart failure in the Cardiology Department and are followed up with a physiotherapy program. Individuals will be randomized into a kinesthetic brain exercise program group (n=20) and a control group (n=20). The control group will receive routine medication monitoring as well as a routine physiotherapy program. The education group will receive routine medication monitoring and a routine physiotherapy program, in addition to individual kinesthetic brain exercise training. Kinesthetic brain exercises will be performed for 30 minutes, 2 days a week for 8 weeks. Demographic information of the individuals will be collected; age, gender, body mass index, age at diagnosis, ejection fraction ratio, family history, smoking status (years/pack). Cognitive function; The Montreal Cognitive Assessment Scale (MoCA), quality of life using the Minnesota Heart Failure Living Questionnaire, and cognitive performance using the Standardized Minimental Test (SMMT) will be used for evaluation. Biochemical analyses will be performed using the Brain-Derived Neurotrophic Factor (BDNF) ELISA kit. Patients in both groups will be evaluated by a physiotherapist before the study and at week 8.

Conditions

Heart

Keywords

Heart failure; cognitive function

Outcome Measures

Primary Outcomes (3)

• Cognitive Function

  Cognitive function will be assessed using the Montreal Cognitive Assessment Scale (MoCA). The MoCA was developed as a rapid screening test for mild cognitive impairment. The MoCA assesses various cognitive functions, including attention and concentration, executive functions, memory, language, visual construction skills, abstract thinking, calculation, and orientation. The test is scored between 0 and 30 points. A score of 21 or higher is considered normal.

  Initially and after 8 weeks

• Biochemical analyses

  Brain-derived neurotrophic factor (BDNF) will be examined through biochemical analyses.

  Initially and after 8 weeks

• Cognitive Performance

  The Standardized Mini-Mental Test (SMMT) will be used to assess cognitive performance. Test scores range from 0 to 30. The threshold for the Mini-Mental Test is 22-23 for educated individuals and 18-19 for uneducated individuals. In assessments for individuals with dementia, scores between 25-30 indicate normal cognitive function, 21-24 indicate mild dementia, 10-20 indicate mild-to-moderate dementia, and 0-9 indicate advanced dementia.

  Initially and after 8 weeks

Secondary Outcomes (1)

• Quality of life in heart failure

  Initially and after 8 weeks

Study Arms (2)

Exercise

EXPERIMENTAL

Other: Kinesthetic brain exercises; Other: Cardiorespiratory Physiotherapy; Drug: Heart Failure drugs

Control

ACTIVE COMPARATOR

Other: Cardiorespiratory Physiotherapy; Drug: Heart Failure drugs

Interventions

Kinesthetic brain exercises OTHER

Kinesthetic brain exercises are a series of movements designed to connect the body and mind, encourage the use of brain hemispheres through physical and mental strategies, and also improve and strengthen cognitive functions for learning.

Exercise

Cardiorespiratory Physiotherapy OTHER

This is the standard physiotherapy procedure applied to patients with heart failure. It includes practices aimed at improving breathing, improving respiratory muscle strength, and providing mobilization. It encompasses breathing exercises, functional mobility exercises, stretching and flexibility exercises for the upper and lower extremities, etc.

Control; Exercise

Heart Failure drugs DRUG

Continued use of medications prescribed by the cardiologist, under the supervision of the doctor.

Control; Exercise

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with heart failure
• Between 30-65 years of age
• No history of cardiac surgery
• Cooperative patients

You may not qualify if:

• Diagnosed with or having a history of neurological disease
• Pregnant or suspected of being pregnant
• Scoring above 24 on the Mini Mental Test
• Patients for whom exercise is contraindicated
• Individuals with a history of orthopedic surgery

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University

Izmir, Karsiyaka, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 11, 2026
• First Posted: February 18, 2026
• Study Start: February 11, 2026
• Primary Completion: April 15, 2026
• Study Completion (Estimated): October 15, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)