NCT07417475

Brief Summary

This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval. Patients with clinically localized prostate cancer eligible for bilateral nerve-sparing surgery were enrolled. Two surgical techniques-anterior-posterior reconstruction (APR) and the HOOD technique-were compared. All procedures were performed by a single high-volume surgeon at a tertiary referral center. The primary endpoint was early urinary continence recovery, assessed at catheter removal and at 3, 6, and 12 weeks postoperatively. Secondary outcomes included postoperative complications, positive surgical margin rates, and early oncological outcomes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2024

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2024

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

February 11, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 18, 2026

Completed
Last Updated

February 18, 2026

Status Verified

February 1, 2026

Enrollment Period

2 years

First QC Date

February 11, 2026

Last Update Submit

February 11, 2026

Conditions

Prostate Cancer (Adenocarcinoma)

Keywords

HOOD techniqueProstate cancerNerve-sparing

Outcome Measures

Primary Outcomes (1)

  • Functional outcomes

    The Urinary continance recovery rates at the catheter removal, and subsequently at 3 weeks , 6 weeks and 12 weeks after surgery.

    3 weeks , 6 weeks and 12 weeks after surgery.

Study Arms (2)

HOOD technique

EXPERIMENTAL
Procedure: Prostatectomy with HOOD techinque

Anterior-Posterior reconstruction

ACTIVE COMPARATOR
Procedure: Prostatectomy with anterior-posterior renconstruciton

Interventions

Prostatectomy with anterior-posterior renconstrucitonPROCEDURE

Prostatectomy with anterior-posterior reconstruction involves restoration of both the posterior musculofascial plate and the anterior periurethral support structures during vesicourethral anastomosis, aiming to re-establish normal pelvic anatomy and improve early postoperative urinary continence following radical prostatectomy.

Anterior-Posterior reconstruction
Prostatectomy with HOOD techinquePROCEDURE

Prostatectomy with the HOOD (Hood technique) is a nerve-sparing approach in which the anterior periprostatic structures, including the detrusor apron and puboprostatic ligaments, are preserved to maintain anterior urethral support and neurovascular integrity, with the aim of improving early urinary continence and functional recovery after radical prostatectomy.

HOOD technique

Eligibility Criteria

Age40 Years - 75 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • life expectancy \>10 years,
  • clinically organ confined disease (cT1-cT2),
  • biopsy ISUP GG ≤3,
  • total serum prostate-specific antigen (PSA) ≤10 ng/ml
  • normal preoperative continence and potency

You may not qualify if:

  • high risk prosatate cancer
  • cN1
  • M1 prostate cancer (according to preoperative GA68 PSMA PET CT)
  • pre-existing urinary incontinence,
  • previous prostatic, urethral, bladder neck surgery
  • neoadjuvant therapy
  • prior pelvic radiotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ankara Universtity School of medicine department of urology

Ankara, Turkey (Türkiye)

Location

Related Publications (8)

  • Mandel A, Choudhary M, Tillu N, Maheshwari A, Kolanukuduru K, Wagaskar V, Tewari A. Hood Technique for Radical Prostatectomy. J Endourol. 2025 Mar;39(S1):S35-S38. doi: 10.1089/end.2024.0303.

    PMID: 40100831BACKGROUND

  • Turkolmez K, Akpinar C, Kubilay E, Suer E. Retzius-Sparing vs Modified Anatomical Structure Preserving and Retzius-Repairing Robotic-Assisted Radical Prostatectomy: A Prospective Randomized Comparison on Functional Outcomes with a 1-Year Follow-Up. J Endourol. 2022 Sep;36(9):1214-1222. doi: 10.1089/end.2022.0073. Epub 2022 Jun 2.

    PMID: 35546454BACKGROUND

  • Tewari AK, Bigelow K, Rao S, Takenaka A, El-Tabi N, Te A, Vaughan ED. Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar: a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy. Urology. 2007 Apr;69(4):726-31. doi: 10.1016/j.urology.2006.12.028.

    PMID: 17445659BACKGROUND

  • Student V Jr, Vidlar A, Grepl M, Hartmann I, Buresova E, Student V. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-assisted Radical Prostatectomy: One-year Functional Outcomes in a Two-group Randomised Controlled Trial. Eur Urol. 2017 May;71(5):822-830. doi: 10.1016/j.eururo.2016.05.032. Epub 2016 Jun 6.

    PMID: 27283216BACKGROUND

  • Porpiglia F, Bertolo R, Manfredi M, De Luca S, Checcucci E, Morra I, Passera R, Fiori C. Total Anatomical Reconstruction During Robot-assisted Radical Prostatectomy: Implications on Early Recovery of Urinary Continence. Eur Urol. 2016 Mar;69(3):485-95. doi: 10.1016/j.eururo.2015.08.005. Epub 2015 Aug 19.

    PMID: 26297603BACKGROUND

  • Mather JS. Impossible direct laryngoscopy in achondroplasia. A case report. Anaesthesia. 1966 Apr;21(2):244-8. doi: 10.1111/j.1365-2044.1966.tb02607.x. No abstract available.

    PMID: 5956576BACKGROUND

  • Heesakkers J, Farag F, Bauer RM, Sandhu J, De Ridder D, Stenzl A. Pathophysiology and Contributing Factors in Postprostatectomy Incontinence: A Review. Eur Urol. 2017 Jun;71(6):936-944. doi: 10.1016/j.eururo.2016.09.031. Epub 2016 Oct 6.

    PMID: 27720536BACKGROUND

  • Cambio AJ, Evans CP. Minimising postoperative incontinence following radical prostatectomy: considerations and evidence. Eur Urol. 2006 Nov;50(5):903-13; discussion 913. doi: 10.1016/j.eururo.2006.08.009. Epub 2006 Aug 28.

    PMID: 16956715BACKGROUND

MeSH Terms

Conditions

Prostatic NeoplasmsAdenocarcinoma

Interventions

Prostatectomy

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital DiseasesCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

Urologic Surgical Procedures, MaleUrologic Surgical ProceduresUrogenital Surgical ProceduresSurgical Procedures, Operative

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

February 11, 2026

First Posted

February 18, 2026

Study Start

January 1, 2024

Primary Completion

January 1, 2026

Study Completion

January 1, 2026

Last Updated

February 18, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)